Abstract
The in vitro activity of cefixime against 2,458 clinical isolates of Haemophilus influenzae was determined. All the strains were inhibited by less than or equal to 2 micrograms of cefixime per ml, and the modal MIC was 0.03 micrograms/ml. Activity was unaffected by the presence of beta-lactamase produced by 157 isolates. Nineteen of the twenty-four isolates for which cefixime MICs were greater than or equal to 0.5 micrograms/ml were beta-lactamase negative but showed reduced susceptibility to ampicillin.
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Selected References
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- Brittain D. C., Scully B. E., Hirose T., Neu H. C. The pharmacokinetic and bactericidal characteristics of oral cefixime. Clin Pharmacol Ther. 1985 Nov;38(5):590–594. doi: 10.1038/clpt.1985.229. [DOI] [PubMed] [Google Scholar]
- Catlin B. W. Iodometric detection of Haemophilus influenzae beta-lactamase: rapid presumptive test for ampicillin resistance. Antimicrob Agents Chemother. 1975 Mar;7(3):265–270. doi: 10.1128/aac.7.3.265. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Fuchs P. C., Barry A. L., Jones R. N. Cefixime disk susceptibility test criteria. J Clin Microbiol. 1986 Oct;24(4):647–649. doi: 10.1128/jcm.24.4.647-649.1986. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Howard A. J., Hince C. J., Williams J. D. Antibiotic resistance in Streptococcus pneumoniae and Haemophilus influenzae. Report of a study group on bacterial resistance. Br Med J. 1978 Jun 24;1(6128):1657–1660. doi: 10.1136/bmj.1.6128.1657. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kamimura T., Kojo H., Matsumoto Y., Mine Y., Goto S., Kuwahara S. In vitro and in vivo antibacterial properties of FK 027, a new orally active cephem antibiotic. Antimicrob Agents Chemother. 1984 Jan;25(1):98–104. doi: 10.1128/aac.25.1.98. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kilian M. A rapid method for the differentiation of Haemophilus strains. The porphyrin test;. Acta Pathol Microbiol Scand B Microbiol Immunol. 1974 Dec;82(6):835–842. doi: 10.1111/j.1699-0463.1974.tb02381.x. [DOI] [PubMed] [Google Scholar]
- Neu H. C., Chin N. X., Labthavikul P. Comparative in vitro activity and beta-lactamase stability of FR 17027, a new orally active cephalosporin. Antimicrob Agents Chemother. 1984 Aug;26(2):174–180. doi: 10.1128/aac.26.2.174. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Philpott-Howard J., Williams J. D. Increase in antibiotic resistance in Haemophilus influenzae in the United Kingdom since 1977: report of study group. Br Med J (Clin Res Ed) 1982 May 29;284(6329):1597–1599. doi: 10.1136/bmj.284.6329.1597. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Powell M., Koutsia-Carouzou C., Voutsinas D., Seymour A., Williams J. D. Resistance of clinical isolates of Haemophilus influenzae in United Kingdom 1986. Br Med J (Clin Res Ed) 1987 Jul 18;295(6591):176–179. doi: 10.1136/bmj.295.6591.176. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Sakamoto H., Hirose T., Mine Y. Pharmacokinetics of FK027 in rats and dogs. J Antibiot (Tokyo) 1985 Apr;38(4):496–504. doi: 10.7164/antibiotics.38.496. [DOI] [PubMed] [Google Scholar]
- Sakamoto H., Hirose T., Nakamoto S., Mine Y. Mechanism of renal excretion of FK027 in dogs and rabbits. J Antibiot (Tokyo) 1985 Aug;38(8):1088–1095. doi: 10.7164/antibiotics.38.1088. [DOI] [PubMed] [Google Scholar]
- Williams J. D., Kattan S., Cavanagh P. Letter: Penicillinase production by Haemophilus influenzae. Lancet. 1974 Jul 13;2(7872):103–103. doi: 10.1016/s0140-6736(74)91663-8. [DOI] [PubMed] [Google Scholar]