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. 1997 Aug;65(8):3267–3270. doi: 10.1128/iai.65.8.3267-3270.1997

The baboon as a nonhuman primate model for assessing the effects of maternal immunization with Haemophilus influenzae type b polysaccharide vaccines.

M H Shearer 1, A H Lucas 1, P W Anderson 1, K D Carey 1, H B Jenson 1, T C Chanh 1, J R Stanley 1, R C Kennedy 1
PMCID: PMC175462  PMID: 9234785

Abstract

These studies were performed to assess the utility of the baboon as a nonhuman primate model to evaluate vaccines for use in humans. Specifically, we examined the antibody response of baboons immunized during the third trimester of pregnancy with Haemophilus influenzae type b (Hib) polyribosylribitol phosphate (PRP) conjugate and unconjugated polysaccharide vaccines. Some of the vaccinated mothers failed to respond to a single immunization with unconjugated Hib PRP. Specific Hib PRP immunoglobulin G (IgG) but not IgM antibodies cross the baboon placenta and are detected in the offspring. Higher-titer baboon anti-Hib PRP did not express two previously defined cross-reactive human anti-Hib PRP idiotypes and was biased towards lambda light-chain expression. Spectrotype analysis indicated that baboon anti-Hib PRP was restricted in heterogeneity and oligoclonal.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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