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. 1997 Oct;65(10):4360–4364. doi: 10.1128/iai.65.10.4360-4364.1997

Hemin induces germ tube formation in Candida albicans.

M Casanova 1, A M Cervera 1, D Gozalbo 1, J P Martínez 1
PMCID: PMC175626  PMID: 9317050

Abstract

Hemin induced germination of Candida albicans blastoconidia when cells grown up to the early exponential phase were shifted from 28 to 37 degrees C (70 to 75% of cells exhibited germ tubes). N-Acetyl-D-glucosamine (GlcNAc), another inducer of myceliation in this fungus, caused a similar effect. The combination of hemin and GlcNAc resulted in a higher percentage (95%) of blastoconidial germination. These results suggest that in addition to temperature, hemin levels and carbon source may coordinately regulate the expression of subsets of genes involved in the yeast-to-mycelium transition in C. albicans.

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Selected References

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