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. 1987 Dec;31(12):1897–1900. doi: 10.1128/aac.31.12.1897

Formulation, toxicity, and antifungal activity in vitro of liposome-encapsulated nystatin as therapeutic agent for systemic candidiasis.

R T Mehta 1, R L Hopfer 1, L A Gunner 1, R L Juliano 1, G Lopez-Berestein 1
PMCID: PMC175823  PMID: 3439798

Abstract

Multilamellar vesicles containing nystatin (NYS) were compared with vesicles containing the free drug for toxicity to erythrocytes and for antifungal activity in vitro. Liposomal nystatin was as active as free NYS was against a wide variety of yeasts and fungi. The antifungal activity against Candida albicans was maintained with different liposome compositions and without sterols. Liposome encapsulation also protected the erythrocytes from the toxicity of free NYS.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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