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. 1987 Dec;31(12):1901–1903. doi: 10.1128/aac.31.12.1901

Toxicity and therapeutic effects in mice of liposome-encapsulated nystatin for systemic fungal infections.

R T Mehta 1, R L Hopfer 1, T McQueen 1, R L Juliano 1, G Lopez-Berestein 1
PMCID: PMC175824  PMID: 3439799

Abstract

The therapeutic activity of nystatin (NYS) incorporated in multilamellar liposomes (L-NYS) was studied in vivo. Hale-Stoner mice injected intravenously with various doses of L-NYS and free NYS showed a significant reduction in toxicity of NYS after the NYS was incorporated into liposomes (maximal tolerated doses, 16 and 4 mg/kg of body weight, respectively). The maximal tolerated dose of free NYS had no effect in the treatment of mice infected with Candida albicans, whereas L-NYS at an equivalent dose improved the survival of mice. A marked increase in survival was observed when L-NYS was administered in higher and multiple doses (total doses up to 80 mg/kg). Liposome encapsulation thus provided a means for intravenous administration of NYS, reducing its toxicity and making it an active systemic antifungal agent.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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