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. 1988 Nov;32(11):1680–1683. doi: 10.1128/aac.32.11.1680

Sensitization by heat treatment of Escherichia coli K-12 cells to hydrophobic antibacterial compounds.

T Tsuchido 1, M Takano 1
PMCID: PMC175951  PMID: 3075437

Abstract

The sensitivities of intact and heat-injured cells of Escherichia coli K-12 to several antibacterial compounds were measured by the prolongation of growth delay. Cells exposed to sublethal heat became more sensitive to various hydrophobic compounds, such as medium-chain fatty acids, alkyl esters of p-hydroxybenzoic acid, and some kinds of antibiotics or dyes, than unheated cells; but there was a smaller or no increase in sensitivity to short-chain fatty acids, chloramphenicol, and vancomycin. The destruction by heat of a permeability barrier of the outer membrane may have sensitized the cells to hydrophobic compounds. The sensitization was much lower for a strain defective in lipopolysaccharide, which is important as a barrier against hydrophobic compounds.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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