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. 1988 Nov;32(11):1740–1741. doi: 10.1128/aac.32.11.1740

Evaluation of single-dose ciprofloxacin in the eradication of Neisseria meningitidis from nasopharyngeal carriers.

D L Dworzack 1, C C Sanders 1, E A Horowitz 1, J M Allais 1, M Sookpranee 1, W E Sanders Jr 1, F M Ferraro 1
PMCID: PMC175963  PMID: 3252755

Abstract

The ability of a single oral 750-mg dose of ciprofloxacin to eradicate Neisseria meningitidis from persistent nasopharyngeal carriers was prospectively evaluated in a placebo-controlled, randomized, double-blinded study. Cultures of specimens taken from all 23 ciprofloxacin-dosed subjects 1 day postdose were negative; cultures from 96% of these subjects were negative at 7 and 21 days postdose, including a specimen from a subject colonized with a minocycline-resistant strain. Of 22 placebo recipients, 20 (91%) remained culture positive. Single-dose ciprofloxacin appears efficacious for meningococcal prophylaxis.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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