Skip to main content
NCBI home page
Antimicrobial Agents and Chemotherapy logoLink to Antimicrobial Agents and Chemotherapy
. 1984 Sep;26(3):347–350. doi: 10.1128/aac.26.3.347

Comparative penetration of cefonicid and cefazolin into the atrial appendage and pericardial fluid of patients undergoing open-heart surgery.

M N Dudley, C H Nightingale, A D Drezner, H B Low, R Quintiliani
PMCID: PMC176167  PMID: 6334490

Abstract

The penetration of cefonicid and cefazolin into cardiac tissue was compared after a single 30-mg/kg dose in 30 patients undergoing aortocoronary artery bypass graft surgery. Samples of the right atrial appendage, pericardial fluid, and serum were obtained at various times and assayed for drug content. The concentrations of cefonicid in serum and the atrial appendage were at least twice those observed for cefazolin at a given time after a dose. The mean (+/- standard deviation) atrial appendage-serum ratio was 0.47 +/- 0.14 for cefonicid and 0.34 +/- 0.06 for cefazolin (P less than 0.005). Pericardial fluid concentrations of cefonicid were slightly lower than those observed in patients receiving cefazolin (P greater than 0.05). A single intravenous dose of cefonicid provides high and sustained concentrations in serum and cardiac tissue and thus may be useful in antibiotic prophylaxis of certain surgical procedures; however, further study of the efficacy of this agent in the prevention and treatment of infections associated with Staphylococcus spp. is needed.

Full text

PDF
347

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ALEXANDER J. W., ALTEMEIER W. A. PENICILLIN PROPHYLAXIS OF EXPERIMENTAL STAPHYLOCOCCAL WOUND INFECTIONS. Surg Gynecol Obstet. 1965 Feb;120:243–254. [PubMed] [Google Scholar]
  2. Barza M., Brusch J., Bergeron M. G., Weinstein L. Penetration of antibiotics into fibrin loci in vivo. 3. Intermittent vs. continuous infusion and the effect of probenecid. J Infect Dis. 1974 Jan;129(1):73–78. doi: 10.1093/infdis/129.1.73. [DOI] [PubMed] [Google Scholar]
  3. Burke J. F. The effective period of preventive antibiotic action in experimental incisions and dermal lesions. Surgery. 1961 Jul;50:161–168. [PubMed] [Google Scholar]
  4. Conte J. E., Jr, Cohen S. N., Roe B. B., Elashoff R. M. Antibiotic prophylaxis and cardiac surgery. A prospective double-blind comparison of single-dose versus multiple-dose regimens. Ann Intern Med. 1972 Jun;76(6):943–949. doi: 10.7326/0003-4819-76-6-943. [DOI] [PubMed] [Google Scholar]
  5. DiPiro J. T., Record K. E., Schanzenbach K. S., Bivins B. A. Antimicrobial prophylaxis in surgery: part 2. Am J Hosp Pharm. 1981 Apr;38(4):487–494. [PubMed] [Google Scholar]
  6. Dudley M. N., Nightingale C. H., Quintiliani R., Tilton R. C. In vitro activity of cefonicid, ceforanide, and cefazolin against Staphylococcus aureus and Staphylococcus epidermidis and the effect of human serum. J Infect Dis. 1983 Jul;148(1):178–178. doi: 10.1093/infdis/148.1.178. [DOI] [PubMed] [Google Scholar]
  7. Goldmann D. A., Hopkins C. C., Karchmer A. W., Abel R. M., McEnany M. T., Akins C., Buckley M. J., Moellering R. C., Jr Cephalothin prophylaxis in cardiac valve surgery. A prospective, double-blind comparison of two-day and six-day regimens. J Thorac Cardiovasc Surg. 1977 Mar;73(3):470–479. [PubMed] [Google Scholar]
  8. Guglielmo B. J., Hohn D. C., Koo P. J., Hunt T. K., Sweet R. L., Conte J. E., Jr Antibiotic prophylaxis in surgical procedures. A critical analysis of the literature. Arch Surg. 1983 Aug;118(8):943–955. doi: 10.1001/archsurg.1983.01390080045013. [DOI] [PubMed] [Google Scholar]
  9. Hirschmann J. V., Inui T. S. Antimicrobial prophylaxis: a critique of recent trials. Rev Infect Dis. 1980 Jan-Feb;2(1):1–23. doi: 10.1093/clinids/2.1.1. [DOI] [PubMed] [Google Scholar]
  10. Kluge R. M., Calia F. M., McLaughlin J. S., Hornick R. B. Sources of contamination in open heart surgery. JAMA. 1974 Dec 4;230(10):1415–1418. [PubMed] [Google Scholar]
  11. Quintiliani R., French M., Nightingale C. H. First and second generation cephalosporins. Med Clin North Am. 1982 Jan;66(1):183–197. doi: 10.1016/s0025-7125(16)31452-3. [DOI] [PubMed] [Google Scholar]
  12. Sterling R. P., Connor D. J., Norman J. C., Cooley D. A. Cefonicid concentrations in serum and atrial tissue during open-heart surgery. Antimicrob Agents Chemother. 1983 May;23(5):790–792. doi: 10.1128/aac.23.5.790. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Tan J. S., Holmes J. C., Fowler N. O., Manitsas G. T., Phair J. P. Antibiotic levels in pericardial fluid. J Clin Invest. 1974 Jan;53(1):7–12. doi: 10.1172/JCI107561. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Antimicrobial Agents and Chemotherapy are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES