Skip to main content
Thorax logoLink to Thorax
. 1998 Aug;53(Suppl 2):S52–S57. doi: 10.1136/thx.53.2008.s52

Effects of anti-IgE in asthmatic subjects

A J Frew
PMCID: PMC1765897  PMID: 10193349

Full Text

The Full Text of this article is available as a PDF (109.7 KB).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bentley A. M., Maestrelli P., Saetta M., Fabbri L. M., Robinson D. S., Bradley B. L., Jeffery P. K., Durham S. R., Kay A. B. Activated T-lymphocytes and eosinophils in the bronchial mucosa in isocyanate-induced asthma. J Allergy Clin Immunol. 1992 Apr;89(4):821–829. doi: 10.1016/0091-6749(92)90437-7. [DOI] [PubMed] [Google Scholar]
  2. Bentley A. M., Menz G., Storz C., Robinson D. S., Bradley B., Jeffery P. K., Durham S. R., Kay A. B. Identification of T lymphocytes, macrophages, and activated eosinophils in the bronchial mucosa in intrinsic asthma. Relationship to symptoms and bronchial responsiveness. Am Rev Respir Dis. 1992 Aug;146(2):500–506. doi: 10.1164/ajrccm/146.2.500. [DOI] [PubMed] [Google Scholar]
  3. Bettler B., Texido G., Raggini S., Rüegg D., Hofstetter H. Immunoglobulin E-binding site in Fc epsilon receptor (Fc epsilon RII/CD23) identified by homolog-scanning mutagenesis. J Biol Chem. 1992 Jan 5;267(1):185–191. [PubMed] [Google Scholar]
  4. Boulet L. P., Chapman K. R., Côté J., Kalra S., Bhagat R., Swystun V. A., Laviolette M., Cleland L. D., Deschesnes F., Su J. Q. Inhibitory effects of an anti-IgE antibody E25 on allergen-induced early asthmatic response. Am J Respir Crit Care Med. 1997 Jun;155(6):1835–1840. doi: 10.1164/ajrccm.155.6.9196083. [DOI] [PubMed] [Google Scholar]
  5. Bradding P., Feather I. H., Howarth P. H., Mueller R., Roberts J. A., Britten K., Bews J. P., Hunt T. C., Okayama Y., Heusser C. H. Interleukin 4 is localized to and released by human mast cells. J Exp Med. 1992 Nov 1;176(5):1381–1386. doi: 10.1084/jem.176.5.1381. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Bradding P., Roberts J. A., Britten K. M., Montefort S., Djukanovic R., Mueller R., Heusser C. H., Howarth P. H., Holgate S. T. Interleukin-4, -5, and -6 and tumor necrosis factor-alpha in normal and asthmatic airways: evidence for the human mast cell as a source of these cytokines. Am J Respir Cell Mol Biol. 1994 May;10(5):471–480. doi: 10.1165/ajrcmb.10.5.8179909. [DOI] [PubMed] [Google Scholar]
  7. Broide D. H., Paine M. M., Firestein G. S. Eosinophils express interleukin 5 and granulocyte macrophage-colony-stimulating factor mRNA at sites of allergic inflammation in asthmatics. J Clin Invest. 1992 Oct;90(4):1414–1424. doi: 10.1172/JCI116008. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Casale T. B., Bernstein I. L., Busse W. W., LaForce C. F., Tinkelman D. G., Stoltz R. R., Dockhorn R. J., Reimann J., Su J. Q., Fick R. B., Jr Use of an anti-IgE humanized monoclonal antibody in ragweed-induced allergic rhinitis. J Allergy Clin Immunol. 1997 Jul;100(1):110–121. doi: 10.1016/s0091-6749(97)70202-1. [DOI] [PubMed] [Google Scholar]
  9. Chan-Yeung M., Lam S., Koener S. Clinical features and natural history of occupational asthma due to western red cedar (Thuja plicata). Am J Med. 1982 Mar;72(3):411–415. doi: 10.1016/0002-9343(82)90497-1. [DOI] [PubMed] [Google Scholar]
  10. Chan-Yeung M., Leriche J., Maclean L., Lam S. Comparison of cellular and protein changes in bronchial lavage fluid of symptomatic and asymptomatic patients with red cedar asthma on follow-up examination. Clin Allergy. 1988 Jul;18(4):359–365. doi: 10.1111/j.1365-2222.1988.tb02883.x. [DOI] [PubMed] [Google Scholar]
  11. Corrigan C. J. Elevated interleukin-4 secretion by T lymphocytes: a feature of atopy or of asthma? Clin Exp Allergy. 1995 Jun;25(6):485–487. doi: 10.1111/j.1365-2222.1995.tb01084.x. [DOI] [PubMed] [Google Scholar]
  12. Davidson A. C., Emberlin J., Cook A. D., Venables K. M. A major outbreak of asthma associated with a thunderstorm: experience of accident and emergency departments and patients' characteristics. Thames Regions Accident and Emergency Trainees Association. BMJ. 1996 Mar 9;312(7031):601–604. doi: 10.1136/bmj.312.7031.601. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Davis F. M., Gossett L. A., Pinkston K. L., Liou R. S., Sun L. K., Kim Y. W., Chang N. T., Chang T. W., Wagner K., Bews J. Can anti-IgE be used to treat allergy? Springer Semin Immunopathol. 1993;15(1):51–73. doi: 10.1007/BF00204626. [DOI] [PubMed] [Google Scholar]
  14. Ehnert B., Lau-Schadendorf S., Weber A., Buettner P., Schou C., Wahn U. Reducing domestic exposure to dust mite allergen reduces bronchial hyperreactivity in sensitive children with asthma. J Allergy Clin Immunol. 1992 Jul;90(1):135–138. doi: 10.1016/s0091-6749(06)80024-2. [DOI] [PubMed] [Google Scholar]
  15. Fahy J. V., Fleming H. E., Wong H. H., Liu J. T., Su J. Q., Reimann J., Fick R. B., Jr, Boushey H. A. The effect of an anti-IgE monoclonal antibody on the early- and late-phase responses to allergen inhalation in asthmatic subjects. Am J Respir Crit Care Med. 1997 Jun;155(6):1828–1834. doi: 10.1164/ajrccm.155.6.9196082. [DOI] [PubMed] [Google Scholar]
  16. Frew A. J., Chan H., Lam S., Chan-Yeung M. Bronchial inflammation in occupational asthma due to western red cedar. Am J Respir Crit Care Med. 1995 Feb;151(2 Pt 1):340–344. doi: 10.1164/ajrccm.151.2.7842189. [DOI] [PubMed] [Google Scholar]
  17. Garlisi C. G., Falcone A., Billah M. M., Egan R. W., Umland S. P. T cells are the predominant source of interleukin-5 but not interleukin-4 mRNA expression in the lungs of antigen-challenged allergic mice. Am J Respir Cell Mol Biol. 1996 Sep;15(3):420–428. doi: 10.1165/ajrcmb.15.3.8810648. [DOI] [PubMed] [Google Scholar]
  18. Humbert M., Durham S. R., Ying S., Kimmitt P., Barkans J., Assoufi B., Pfister R., Menz G., Robinson D. S., Kay A. B. IL-4 and IL-5 mRNA and protein in bronchial biopsies from patients with atopic and nonatopic asthma: evidence against "intrinsic" asthma being a distinct immunopathologic entity. Am J Respir Crit Care Med. 1996 Nov;154(5):1497–1504. doi: 10.1164/ajrccm.154.5.8912771. [DOI] [PubMed] [Google Scholar]
  19. Johnston S. L., Pattemore P. K., Sanderson G., Smith S., Lampe F., Josephs L., Symington P., O'Toole S., Myint S. H., Tyrrell D. A. Community study of role of viral infections in exacerbations of asthma in 9-11 year old children. BMJ. 1995 May 13;310(6989):1225–1229. doi: 10.1136/bmj.310.6989.1225. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Jung T., Schauer U., Rieger C., Wagner K., Einsle K., Neumann C., Heusser C. Interleukin-4 and interleukin-5 are rarely co-expressed by human T cells. Eur J Immunol. 1995 Aug;25(8):2413–2416. doi: 10.1002/eji.1830250843. [DOI] [PubMed] [Google Scholar]
  21. Lockey R. F., Benedict L. M., Turkeltaub P. C., Bukantz S. C. Fatalities from immunotherapy (IT) and skin testing (ST) J Allergy Clin Immunol. 1987 Apr;79(4):660–677. doi: 10.1016/s0091-6749(87)80164-1. [DOI] [PubMed] [Google Scholar]
  22. Lopez A. F., Sanderson C. J., Gamble J. R., Campbell H. D., Young I. G., Vadas M. A. Recombinant human interleukin 5 is a selective activator of human eosinophil function. J Exp Med. 1988 Jan 1;167(1):219–224. doi: 10.1084/jem.167.1.219. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Maestrelli P., Occari P., Turato G., Papiris S. A., Di Stefano A., Mapp C. E., Milani G. F., Fabbri L. M., Saetta M. Expression of interleukin (IL)-4 and IL-5 proteins in asthma induced by toluene diisocyanate (TDI). Clin Exp Allergy. 1997 Nov;27(11):1292–1298. [PubMed] [Google Scholar]
  24. Martinez F. D., Wright A. L., Taussig L. M., Holberg C. J., Halonen M., Morgan W. J. Asthma and wheezing in the first six years of life. The Group Health Medical Associates. N Engl J Med. 1995 Jan 19;332(3):133–138. doi: 10.1056/NEJM199501193320301. [DOI] [PubMed] [Google Scholar]
  25. Mauser P. J., Pitman A., Witt A., Fernandez X., Zurcher J., Kung T., Jones H., Watnick A. S., Egan R. W., Kreutner W. Inhibitory effect of the TRFK-5 anti-IL-5 antibody in a guinea pig model of asthma. Am Rev Respir Dis. 1993 Dec;148(6 Pt 1):1623–1627. doi: 10.1164/ajrccm/148.6_Pt_1.1623. [DOI] [PubMed] [Google Scholar]
  26. Presta L. G., Lahr S. J., Shields R. L., Porter J. P., Gorman C. M., Fendly B. M., Jardieu P. M. Humanization of an antibody directed against IgE. J Immunol. 1993 Sep 1;151(5):2623–2632. [PubMed] [Google Scholar]
  27. Punnonen J., Aversa G., Cocks B. G., de Vries J. E. Role of interleukin-4 and interleukin-13 in synthesis of IgE and expression of CD23 by human B cells. Allergy. 1994 Sep;49(8):576–586. doi: 10.1111/j.1398-9995.1994.tb00122.x. [DOI] [PubMed] [Google Scholar]
  28. Purkerson J., Isakson P. A two-signal model for regulation of immunoglobulin isotype switching. FASEB J. 1992 Nov;6(14):3245–3252. doi: 10.1096/fasebj.6.14.1385241. [DOI] [PubMed] [Google Scholar]
  29. Rawlins M. D., Wood S. M., Mann R. D. Hazards with desensitising vaccines. Arb Paul Ehrlich Inst Bundesamt Sera Impfstoffe Frankf A M. 1988;(82):147–151. [PubMed] [Google Scholar]
  30. Sanderson C. J., Campbell H. D., Young I. G. Molecular and cellular biology of eosinophil differentiation factor (interleukin-5) and its effects on human and mouse B cells. Immunol Rev. 1988 Feb;102:29–50. doi: 10.1111/j.1600-065x.1988.tb00740.x. [DOI] [PubMed] [Google Scholar]

Articles from Thorax are provided here courtesy of BMJ Publishing Group

RESOURCES