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. 1973 May;48(1):48–58. doi: 10.1111/j.1476-5381.1973.tb08221.x

Barbiturate-induced transmitter release at a frog neuromuscular junction

T D Thomson, S A Turkanis
PMCID: PMC1776099  PMID: 4353318

Abstract

1. The influence of barbiturates on neuromuscular transmission at end-plates of frog sartorius muscles was investigated electrophysiologically on preparations bathed in Ringer solution containing a low concentration of calcium and a high concentration of magnesium.

2. Effects of a convulsant barbiturate, 5-(2-cyclohexylideneëthyl)-5-ethyl barbituric acid (CHEB), were compared with those of phenobarbitone.

3. CHEB and phenobarbitone increased the mean quantum content of the end-plate potentials and decreased the mean amplitude of the miniature end-plate potentials.

4. Both barbiturates enhanced the duration of the nerve-terminal action potential and had little or no effect on the effective resistance of the skeletal muscle membrane.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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