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. 1973 Jun;48(2):198–211. doi: 10.1111/j.1476-5381.1973.tb06906.x

β-Adrenoceptor blocking properties and cardioselectivity of M & B 17,803A

B Basil, R Jordan, A H Loveless, D R Maxwell
PMCID: PMC1776183  PMID: 4147427

Abstract

1. The β-adrenoceptor blocking properties of (±)-1-(2-acetyl-4-n-butyramidophenoxy)-2-hydroxy-3-isopropylaminopropane hydrochloride (M&B 17,803A) have been compared with those of practolol and propranolol in the guinea-pig, cat and dog.

2. Following either intravenous or oral administration in the cat or dog, M&B 17,803A and practolol had similar potency in antagonizing isoprenaline-induced tachycardia and both showed cardioselectivity, but both were less potent than propranolol.

3. M&B 17,803A and practolol had approximately one hundredth the intravenous potency of propranolol in increasing the severity of anaphylactic bronchospasm in the conscious sensitized guinea-pig.

4. M&B 17,803A possessed less marked intrinsic sympathomimetic activity than practolol but, like propranolol, it had significant local anaesthetic properties and increased the refractory period of rabbit isolated atria.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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