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. 1973 Oct;49(2):303–310. doi: 10.1111/j.1476-5381.1973.tb08376.x

Effects of chlorpromazine on exploration and habituation in the rat

Sandra E File
PMCID: PMC1776385  PMID: 4793332

Abstract

1. The effects of chlorpromazine, 2 and 4 mg/kg, on exploration were investigated under two independent influences—food deprivation and time of day.

2. Rats had three 3-minute trials in a hole-board apparatus; hole-investigation (head-dips) and general motor activity were recorded.

3. On trial 1 chlorpromazine reduced exploration to half the control level, but on trial 3 it had no effect on motor activity or head-dips.

4. General activity habituated from trial 1 to 3 in all groups, but some of the drug groups did not show significant habituation of head-dips, due to the low level of responding on trial 1.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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