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. 1973 Sep;49(1):106–114. doi: 10.1111/j.1476-5381.1973.tb08272.x

Assessment of selective β-adrenoceptor blockade in man

R H Briant, C T Dollery, T Fenyvesi, C F George
PMCID: PMC1776418  PMID: 4150760

Abstract

1. Selective antagonism of the cardiac β1-adrenoceptors has been studied in normal human volunteers.

2. Practolol and UK 6558 produced greater antagonism of the chronotropic and inotropic responses to i.v. isoprenaline than of the vasodilator response to either i.v. or intra-arterial isoprenaline. A third drug, M&B 17,803A, produced non-selective β-adrenoceptor blockade in 2 of 3 subjects studied.

3. Practolol, UK 6558 and M&B 17,803A, produced an attenuation of the responses to Valsalva's manoeuvre.

4. A substantial reduction in blood pressure was seen in 3 of 4 normotensive subjects given UK 6558.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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