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. 1973 Jan;47(1):161–171. doi: 10.1111/j.1476-5381.1973.tb08170.x

Action of several β-adrenoceptor blocking drugs in the pregnant sheep and foetus

J F Truelove, G R Van Petten, R F Willes
PMCID: PMC1776527  PMID: 4146153

Abstract

1. The effect of several β-adrenoceptor blocking drugs on the pregnant ewe and foetus were studied. Bunolol, butidrine, oxprenolol, propranolol and USVP65-24 all crossed the ovine placenta and produced a β-adrenoceptor blockade in the ovine foetus. AH3474, AY21011 and sotalol did not cross the ovine placenta as assessed by the absence of a β-blockade in the foetus when these compounds were administered to the pregnant ewe.

2. Of the β-blocking compounds tested, only propranolol and oxprenolol produced a prolonged blockade in the foetus. The β-blockade with propranolol was of 3 h duration in the ewe and 10 h duration in the foetus. Oxprenolol produced a β-blockade of 3 h duration in the ewe and 8 h in the foetus.

3. The β-blocking drugs which did cross the ovine placenta were more soluble in organic solvents (ether, chloroform, corn oil and olive oil) than those which did not cross the ovine placenta.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Barden T. P., Stander R. W. Effects of adrenergic blocking agents and catecholamines in human pregnancy. Am J Obstet Gynecol. 1968 Sep 15;102(2):226–235. doi: 10.1016/0002-9378(68)90323-2. [DOI] [PubMed] [Google Scholar]
  2. Bauer G. E., Michell G. Oxprenolol: clinical experiences with a new beta-adrenergic blocking drug. Med J Aust. 1970 Jan 24;1(4):170–173. doi: 10.5694/j.1326-5377.1970.tb77785.x. [DOI] [PubMed] [Google Scholar]
  3. Blackburn C. H., Byrne L. J., Cullum V. A., Farmer J. B., Levy G. P. The pharmacolgy of 5-(2-t-butylamino-1-hydroxyethyl) salicylamide (ah 3474), a beta-adrenoreceptor blocking agent. J Pharm Pharmacol. 1969 Aug;21(8):488–497. doi: 10.1111/j.2042-7158.1969.tb08299.x. [DOI] [PubMed] [Google Scholar]
  4. ESKES T., STOLTE L., SEELEN J., MOED H. D., VOGELSANG C. EPINEPHRINE DERIVATES AND THE ACTIVITY OF THE HUMAN UTERUS. II. THE INFLUENCE OF PRONETHALOL AND PROPANOLOLT ON THE UTERINE AND SYSTEMIC ACTIVITY OF P-HYDROXYPHENYLISOPROPYLARTERENOL (CC-25). Am J Obstet Gynecol. 1965 Jul 15;92:871–881. doi: 10.1016/s0002-9378(16)34796-2. [DOI] [PubMed] [Google Scholar]
  5. Fitzgerald J. D. Perspectives in adrenergic beta-receptor blockade. Clin Pharmacol Ther. 1969 May-Jun;10(3):292–306. doi: 10.1002/cpt1969103292. [DOI] [PubMed] [Google Scholar]
  6. Ginsburg J. Placental drug transfer. Annu Rev Pharmacol. 1971;11:387–408. doi: 10.1146/annurev.pa.11.040171.002131. [DOI] [PubMed] [Google Scholar]
  7. Joelsson I., Barton M. D. The effect of blockade of the beta receptors of the sympathetic nervous system of the fetus. A preliminary report. Acta Obstet Gynecol Scand. 1969;48(Suppl):75+–75+. doi: 10.3109/00016346909157714. [DOI] [PubMed] [Google Scholar]
  8. Kato R., Takanaka A., Shoji H. Inhibition of drug-metabolizing enzymes of liver microsomes by hydrazine derivatives in relation to their lipid solubility. Jpn J Pharmacol. 1969 Jun;19(2):315–322. doi: 10.1254/jjp.19.315. [DOI] [PubMed] [Google Scholar]
  9. Levy B., Wasserman M. 1-Isopropylamino-3-(4-indanoxy)-2-propanol HC1: a potent beta-adrenoreceptor antagonist. Br J Pharmacol. 1970 May;39(1):139–148. doi: 10.1111/j.1476-5381.1970.tb09563.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Robson R. D., Kaplan H. R. The cardiovascular pharmacology of bunolol, a new beta adrenergic blocking agent. J Pharmacol Exp Ther. 1970 Oct;175(1):157–167. [PubMed] [Google Scholar]
  11. STOLTE L., ESKES T., SEELEN J., MOED H. D., VOGELSANG C. EPINEPHRINE DERIVATES AND THE ACTIVITY OF THE HUMAN UTERUS. I. . THE INHIBITING EFFECT OF P-HYDROXYPHENYLISOPROPYLARTERENOL (CC-25) UPON UTERINE ACTIVITY IN HUMAN PREGNANCY. Am J Obstet Gynecol. 1965 Jul 15;92:865–870. doi: 10.1016/s0002-9378(16)34795-0. [DOI] [PubMed] [Google Scholar]
  12. Sethi A., Chaudhury R. R. Effect of adrenergic receptor-blocking drugs in pregnancy in rats. J Reprod Fertil. 1970 Apr;21(3):551–554. doi: 10.1530/jrf.0.0210551. [DOI] [PubMed] [Google Scholar]
  13. Tunstall M. E. The effect of propranolol on the onset of breathing at birth. Br J Anaesth. 1969 Sep;41(9):792–792. [PubMed] [Google Scholar]
  14. Van Petten G. R., Willes R. F. Beta-adrenoceptive responses in the unanaesthetized ovine foetus. Br J Pharmacol. 1970 May;38(3):572–582. doi: 10.1111/j.1476-5381.1970.tb10598.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Willes R. F., Boda J. M., Manns J. G. Insulin secretion by the ovine fetus in utero. Endocrinology. 1969 Mar;84(3):520–527. doi: 10.1210/endo-84-3-520. [DOI] [PubMed] [Google Scholar]
  16. Willes R. F., Van Petten G. R., Truelove J. F. Chronic exteriorization of vascular cannulas and ECG electrodes from the ovine fetus. J Appl Physiol. 1970 Feb;28(2):248–250. doi: 10.1152/jappl.1970.28.2.248. [DOI] [PubMed] [Google Scholar]

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