Skip to main content
PMC home page
British Journal of Pharmacology logoLink to British Journal of Pharmacology
. 1973 Feb;47(2):305–314. doi: 10.1111/j.1476-5381.1973.tb08328.x

Inhibition of functional vasodilatation and prostaglandin formation in rabbit adipose tissue by indomethacin and aspirin

Barbara Bowery, G P Lewis
PMCID: PMC1776566  PMID: 4352868

Abstract

1. The epigastric adipose depot of rabbits has been used to examine the effect of indomethacin, aspirin and nicotinic acid on the free fatty acid release and blood flow in fat tissue.

2. The prostaglandin formation which occurs in adipose tissue during lipolysis is prevented by indomethacin and aspirin. The corresponding functional vasodilatation which occurs after infusions of lipolytic substances is also abolished by these two anti-inflammatory compounds.

3. This finding is consistent with the theory that prostaglandin E2 is the mediator of functional vasodilatation in adipose tissue.

4. Nicotinic acid sometimes inhibits the release of free fatty acids from adipose tissue by preventing activation of the tissue lipase. In those experiments in which this inhibition occurred, the vasodilatation was also prevented.

5. This finding is consistent with the view that the prostaglandin E2 which mediates the functional vasodilatation, originates in the triglycerides of the fat tissue.

Full text

PDF
306

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Boberg J., Micheli H., Rammer L. Effect of nicotinic acid on ACTH and noradrenaline stimulated lipolysis in the rabbit. II. In vitro studies including comparison with prostaglandin E1. Acta Physiol Scand. 1970 Jul;79(3):299–304. doi: 10.1111/j.1748-1716.1970.tb04730.x. [DOI] [PubMed] [Google Scholar]
  2. Bowery N. G., Lewis G. P., Matthews J. The relationship between functional vasodilatation in adipose tissue and prostaglandin. Br J Pharmacol. 1970 Nov;40(3):437–445. doi: 10.1111/j.1476-5381.1970.tb10625.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. CARLSON L. A., ORO L. The effect of nicotinic acid on the plasma free fatty acid; demonstration of a metabolic type of sympathicolysis. Acta Med Scand. 1962 Dec;172:641–645. doi: 10.1111/j.0954-6820.1962.tb07203.x. [DOI] [PubMed] [Google Scholar]
  4. DUNCOMBE W. G. THE COLORIMETRIC MICRO-DETERMINATION OF NON-ESTERIFIED FATTY ACIDS IN PLASMA. Clin Chim Acta. 1964 Feb;9:122–125. doi: 10.1016/0009-8981(64)90004-x. [DOI] [PubMed] [Google Scholar]
  5. Ferreira S. H., Moncada S., Vane J. R. Indomethacin and aspirin abolish prostaglandin release from the spleen. Nat New Biol. 1971 Jun 23;231(25):237–239. doi: 10.1038/newbio231237a0. [DOI] [PubMed] [Google Scholar]
  6. Lewis G. P., Mattews J. The mechanism of functional vasodilatation in rabbit epigastric adipose tissue. J Physiol. 1970 Mar;207(1):15–30. doi: 10.1113/jphysiol.1970.sp009045. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Lewis G. P., Matthews J. The mobilization of free fatty acids from rabbit adipose tissue in situ. Br J Pharmacol. 1968 Nov;34(3):564–578. doi: 10.1111/j.1476-5381.1968.tb08485.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Mjös O. D., Akre S. Effect of catecholamines on blood flow, oxygen consumption, and release-uptake of free fatty acids in adipose tissue. Scand J Clin Lab Invest. 1971 May;27(3):221–225. doi: 10.3109/00365517109080211. [DOI] [PubMed] [Google Scholar]
  9. Nielsen S. L., Lbitsch V., Larsen O. A., Lassen N. A., Quaade F. Blood flow through human adipose tissue during lipolysis. Scand J Clin Lab Invest. 1968;22(2):124–130. doi: 10.3109/00365516809160956. [DOI] [PubMed] [Google Scholar]
  10. ORO L., WALLENBERG L., ROSELL S. CIRCULATORY AND METABOLIC PROCESSES IN ADIPOSE TISSUE IN VIVO. Nature. 1965 Jan 9;205:178–179. doi: 10.1038/205178a0. [DOI] [PubMed] [Google Scholar]
  11. SAMUELSSON B. ISOLATION AND IDENTIFICATION OF PROSTAGLANDINS FROM HUMAN SEMINAL PLASMA. 18. PROSTAGLANDINS AND RELATED FACTORS. J Biol Chem. 1963 Oct;238:3229–3234. [PubMed] [Google Scholar]
  12. Smith J. B., Willis A. L. Aspirin selectively inhibits prostaglandin production in human platelets. Nat New Biol. 1971 Jun 23;231(25):235–237. doi: 10.1038/newbio231235a0. [DOI] [PubMed] [Google Scholar]
  13. Vane J. R. Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nat New Biol. 1971 Jun 23;231(25):232–235. doi: 10.1038/newbio231232a0. [DOI] [PubMed] [Google Scholar]

Articles from British Journal of Pharmacology are provided here courtesy of The British Pharmacological Society

RESOURCES