Abstract
1 Apomorphine and pilocarpine each produced dose-dependent hypothermic effects in mice. However, the dose-response curve for pilocarpine was steeper than that for apomorphine.
2 Bilateral lesions of the caudate nucleus produced a permanent decrease in sensitivity to apomorphine but had no effect on sensitivity to pilocarpine.
3 Apomorphine and pilocarpine had synergistic effects; i.e. the hypothermic effect was greater following a combination of the drugs than following either drug alone.
4 The effect of apomorphine was antagonized by either haloperidol or scopolamine; only scopolamine antagonized the effect of pilocarpine.
5 These results suggest that a mechanism involving dopaminergic neurones in the caudate nucleus has a modulatory role in temperature regulation.
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Selected References
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