Abstract
1 The intravenous infusion of bombesin produced in intact dogs and, more strikingly in dogs provided with gastric fistulae a sharp increase in plasma levels of immunoreactive gastrin and at the same time a stimulation of gastric acid secretion. Gastrin response was correlated with the dose of bombesin from approximately 0.1 μg kg-1 h-1 (threshold) to 1 μg kg-1 h-1 (maximum gastrin release).
2 Atropine and metiamide reduced or inhibited gastric acid secretion stimulated by bombesin, but did not affect the rise in gastrin levels.
3 Acidification of the whole stomach or of a perfused antral pouch caused a reduced or delayed response to bombesin. However, the inhibitory effect of acidification could be surmounted by prolonging the duration of bombesin infusion.
4 Antrectomy greatly reduced the rise in gastrin levels and the increase in acid gastric secretion produced by bombesin, but left unaffected the gastric secretagogue effect of pentagastrin.
5 It is concluded that bombesin is a potent releaser of gastrin from the antral mucosa.
6 The possible influence of the renal effects evoked by bombesin in the dog on the gastrin response to the polypeptide is discussed.
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Selected References
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