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. 1974 Nov;52(3):419–425. doi: 10.1111/j.1476-5381.1974.tb08611.x

Reversal learning enhanced by lysergic acid diethylamide (LSD)

Concomitant rise in brain 5-hydroxytryptamine levels

AR King, IL Martin, K Arabella Melville
PMCID: PMC1777004  PMID: 4458849

Abstract

1 Small doses of lysergic acid diethylamide (LSD) (12.5-50 μg/kg) consistently facilitated learning of a brightness discrimination reversal.

2 2-Bromo-lysergic acid diethylamide (BOL-148), a structural analogue of LSD, with similar peripheral anti-5-hydroxytrypamine activity but no psychotomimetic properties, had no effect in this learning situation at a similar dose (25 μg/kg).

3 LSD, but not BOL-148, caused a small but significant increase in brain 5-hydroxytryptamine levels, but had no effect on the levels of catecholamines in the brain at 25 μg/kg.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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