Skip to main content
Archives of Disease in Childhood logoLink to Archives of Disease in Childhood
. 1985 Aug;60(8):698–701. doi: 10.1136/adc.60.8.698

Retinopathy of prematurity: incidence and treatment.

S H Reisner, J Amir, M Shohat, R Krikler, I Nissenkorn, I Ben-Sira
PMCID: PMC1777399  PMID: 3839999

Abstract

The incidence of retinopathy of prematurity in infants with a birthweight less than or equal to 2500 g admitted to a tertiary neonatal intensive care unit between 1977 and 1983 was 20% of all survivors. There was a reciprocal relation between birthweight and the incidence of the disease, with an incidence of 68% in infants weighing less than or equal to 1000 g at birth. Cryotherapy of the avascular retina was performed if the acute disease progressed rapidly during stage 3 and the amount of fibrovascular proliferation was mild to moderate with signs of plus disease (presence of appreciable posterior pole vascular tortuosity and dilatation and the presence of engorgement of iris vessels). This method of treatment was performed in 4% of all survivors: in 26% of infants weighing less than or equal to 1000 g at birth and 5% of infants weighing 1001-1500 g. No infants had cicatricial disease greater than stage 2 on follow-up. The absence of any severe cicatricial disease or blindness in this large group of high risk infants suggests that when indicated and performed on the avascular retina cryotherapy may be an important method of treatment.

Full text

PDF
701

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ben-Sira I., Nissenkorn I., Grunwald E., Yassur Y. Treatment of acute retrolental fibroplasia by cryopexy. Br J Ophthalmol. 1980 Oct;64(10):758–762. doi: 10.1136/bjo.64.10.758. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Gunn T. R., Easdown J., Outerbridge E. W., Aranda J. V. Risk factors in retrolental fibroplasia. Pediatrics. 1980 Jun;65(6):1096–1100. [PubMed] [Google Scholar]
  3. Harris G. S., McCormick A. Q. The prophylactic treatment of retrolental fibroplasia. Mod Probl Ophthalmol. 1977;18:364–367. [PubMed] [Google Scholar]
  4. Hindle N. W. Cryotherapy for retinopathy of prematurity to prevent retrolental fibroplasia. Can J Ophthalmol. 1982 Oct;17(5):207–212. [PubMed] [Google Scholar]
  5. Hittner H. M., Godio L. B., Speer M. E., Rudolph A. J., Taylor M. M., Blifeld C., Kretzer F. L. Retrolental fibroplasia: further clinical evidence and ultrastructural support for efficacy of vitamin E in the preterm infant. Pediatrics. 1983 Mar;71(3):423–432. [PubMed] [Google Scholar]
  6. Hittner H. M., Kretzer F. L., Rudolph A. J. Prevention and management of retrolental fibroplasia. Hosp Pract (Off Ed) 1984 Feb;19(2):85-94, 99. doi: 10.1080/21548331.1984.11702746. [DOI] [PubMed] [Google Scholar]
  7. Keith C. G. Visual outcome and effect of treatment in stage III developing retrolental fibroplasia. Br J Ophthalmol. 1982 Jul;66(7):446–449. doi: 10.1136/bjo.66.7.446. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Kingham J. D. Acute retrolental fibroplasia. II. Treatment by cryosurgery. Arch Ophthalmol. 1978 Nov;96(11):2049–2053. doi: 10.1001/archopht.1978.03910060437008. [DOI] [PubMed] [Google Scholar]
  9. Kinsey V. E., Arnold H. J., Kalina R. E., Stern L., Stahlman M., Odell G., Driscoll J. M., Jr, Elliott J. H., Payne J., Patz A. PaO2 levels and retrolental fibroplasia: a report of the cooperative study. Pediatrics. 1977 Nov;60(5):655–668. [PubMed] [Google Scholar]
  10. Kretzer F. L., Hittner H. M., Johnson A. T., Mehta R. S., Godio L. B. Vitamin E and retrolental fibroplasia: ultrastructural support of clinical efficacy. Ann N Y Acad Sci. 1982;393:145–166. doi: 10.1111/j.1749-6632.1982.tb31240.x. [DOI] [PubMed] [Google Scholar]
  11. Lucey J. F., Dangman B. A reexamination of the role of oxygen in retrolental fibroplasia. Pediatrics. 1984 Jan;73(1):82–96. [PubMed] [Google Scholar]
  12. Mousel D. K., Hoyt C. S. Cryotherapy for retinopathy of prematurity. Ophthalmology. 1980 Nov;87(11):1121–1127. doi: 10.1016/s0161-6420(80)35121-x. [DOI] [PubMed] [Google Scholar]
  13. Patz A. Retrolental fibroplasia. Surv Ophthalmol. 1969 Jul;14(1):1–29. [PubMed] [Google Scholar]
  14. Phelps D. L. Vision loss due to retinopathy of prematurity. Lancet. 1981 Mar 14;1(8220 Pt 1):606–606. doi: 10.1016/s0140-6736(81)92047-x. [DOI] [PubMed] [Google Scholar]
  15. Philip A. G., Little G. A., Polivy D. R., Lucey J. F. Neonatal mortality risk for the eighties: the importance of birth weight/gestational age groups. Pediatrics. 1981 Jul;68(1):122–130. [PubMed] [Google Scholar]
  16. Shohat M., Reisner S. H., Krikler R., Nissenkorn I., Yassur Y., Ben-Sira I. Retinopathy of prematurity: incidence and risk factors. Pediatrics. 1983 Aug;72(2):159–163. [PubMed] [Google Scholar]
  17. Svedbergh B., Lindstedt E. Retrolental fibroplasia in Sweden. General survey and selected study on patients born in 1960-1966. Acta Paediatr Scand. 1973 Sep;62(5):458–464. doi: 10.1111/j.1651-2227.1973.tb08138.x. [DOI] [PubMed] [Google Scholar]
  18. Zak T. A. Retinopathy of prematurity. An update on retrolental fibroplasia. N Y State J Med. 1982 Dec;82(13):1795–1796. [PubMed] [Google Scholar]

Articles from Archives of Disease in Childhood are provided here courtesy of BMJ Publishing Group

RESOURCES