Skip to main content
PMC home page
Archives of Disease in Childhood logoLink to Archives of Disease in Childhood
. 1985 Sep;60(9):832–836. doi: 10.1136/adc.60.9.832

Weight gain and height velocity during prolonged first remission from acute lymphoblastic leukaemia.

C P Sainsbury, R G Newcombe, I A Hughes
PMCID: PMC1777474  PMID: 3863545

Abstract

A retrospective analysis of the medical records of 86 children in prolonged remission from acute lymphoblastic leukaemia was performed to calculate changes in the rate of increase in height and weight gain. The rate of increase in height decreased during initial treatment, and the potential for final adult height was not regained. Weight gain was excessive; this started during treatment and persisted into the remission years. Values of weight adjusted for height did not return to values found before treatment until eight years after diagnosis. Several factors can account for this weight gain, but there is a practical need to provide dietary advice, particularly when chemotherapy is stopped.

Full text

PDF
835

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ahmed S. R., Shalet S. M. Hypothalamic growth hormone releasing factor deficiency following cranial irradiation. Clin Endocrinol (Oxf) 1984 Nov;21(5):483–488. doi: 10.1111/j.1365-2265.1984.tb01385.x. [DOI] [PubMed] [Google Scholar]
  2. Barak Y., Liban E. Hypothalamic hyperphagia, obesity and disturbed behaviour in acute leukemia. Acta Paediatr Scand. 1968 Mar;57(2):153–156. doi: 10.1111/j.1651-2227.1968.tb04669.x. [DOI] [PubMed] [Google Scholar]
  3. Bloom H. J., Wallace E. N., Henk J. M. The treatment and prognosis of medulloblastoma in children. A study of 82 verified cases. Am J Roentgenol Radium Ther Nucl Med. 1969 Jan;105(1):43–62. doi: 10.2214/ajr.105.1.43. [DOI] [PubMed] [Google Scholar]
  4. Bray G. A., Gallagher T. F., Jr Manifestations of hypothalamic obesity in man: a comprehensive investigation of eight patients and a reveiw of the literature. Medicine (Baltimore) 1975 Jul;54(4):301–330. doi: 10.1097/00005792-197507000-00002. [DOI] [PubMed] [Google Scholar]
  5. Broomhall J., May R., Lilleyman J. S., Milner R. D. Height and lymphoblastic leukaemia. Arch Dis Child. 1983 Apr;58(4):300–301. doi: 10.1136/adc.58.4.300. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Chilcote R. R., Baehner R. L. Septicemia in association with acute lymphoblastic leukemia. J Pediatr. 1979 May;94(5):715–718. doi: 10.1016/s0022-3476(79)80136-5. [DOI] [PubMed] [Google Scholar]
  7. Cole T. J. A method for assessing age-standardized weight-for-height in children seen cross-sectionally. Ann Hum Biol. 1979 May-Jun;6(3):249–268. doi: 10.1080/03014467900007252. [DOI] [PubMed] [Google Scholar]
  8. Eiser C. Psychological development of the child with leukemia: a review. J Behav Med. 1979 Jun;2(2):141–157. doi: 10.1007/BF00846663. [DOI] [PubMed] [Google Scholar]
  9. Griffin N. K., Wadsworth J. Effect of treatment of malignant disease on growth in children. Arch Dis Child. 1980 Aug;55(8):600–603. doi: 10.1136/adc.55.8.600. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Lewis I. J., Mainwaring D., Martin J. Enteropathy complicating maintenance therapy in acute lymphoblastic leukaemia. Arch Dis Child. 1982 Sep;57(9):663–667. doi: 10.1136/adc.57.9.663. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Maguire G. P. Psychological consequences of childhood leukaemia. J R Soc Med. 1980 Mar;73(3):217–218. doi: 10.1177/014107688007300315. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Park T. S., Hoffman H. J., Hendrick E. B., Humphreys R. P., Becker L. E. Medulloblastoma: clinical presentation and management. Experience at the hospital for sick children, toronto, 1950-1980. J Neurosurg. 1983 Apr;58(4):543–552. doi: 10.3171/jns.1983.58.4.0543. [DOI] [PubMed] [Google Scholar]
  13. Probert J. C., Parker B. R., Kaplan H. S. Growth retardation in children after megavoltage irradiation of the spine. Cancer. 1973 Sep;32(3):634–639. doi: 10.1002/1097-0142(197309)32:3<634::aid-cncr2820320316>3.0.co;2-a. [DOI] [PubMed] [Google Scholar]
  14. Schuler D., Polcz A., Révész T., Koós R., Bakos M., Gál N. Psychological late effects of leukemia in children and their prevention. Med Pediatr Oncol. 1981;9(2):191–194. doi: 10.1002/mpo.2950090214. [DOI] [PubMed] [Google Scholar]
  15. Shalet S. M. Abnormalities of growth and gonadal function in children treated for malignant disease: a review. J R Soc Med. 1982 Aug;75(8):641–647. doi: 10.1177/014107688207500812. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Shalet S. M., Price D. A. Effect of treatment of malignant disease on growth in children. Arch Dis Child. 1981 Mar;56(3):235–236. doi: 10.1136/adc.56.3.235. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Tanner J. M., Whitehouse R. H., Takaishi M. Standards from birth to maturity for height, weight, height velocity, and weight velocity: British children, 1965. II. Arch Dis Child. 1966 Dec;41(220):613–635. doi: 10.1136/adc.41.220.613. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Archives of Disease in Childhood are provided here courtesy of BMJ Publishing Group

RESOURCES