Skip to main content
PMC home page
Archives of Disease in Childhood logoLink to Archives of Disease in Childhood
. 1985 Dec;60(12):1149–1151. doi: 10.1136/adc.60.12.1149

Thyroid dysfunction in Down's syndrome.

M M Loudon, R E Day, E M Duke
PMCID: PMC1777686  PMID: 2936311

Abstract

One hundred and sixteen children with Down's syndrome, living in the community, were examined for clinical or laboratory evidence of thyroid dysfunction. Three were hypothyroid and one was hyperthyroid. Twenty eight (29%) had thyroid autoantibodies. Autoimmune conditions were present in first or second degree relatives of 35 (30%) of the children, and in 17 (15%) this was a thyroid disorder. The families of normal control children also showed a 30% incidence of overt autoimmune conditions, and 19 (16%) families showed overt thyroid disease.

Full text

PDF
1151

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Baxter R. G., Larkins R. G., Martin F. I., Heyma P., Myles K., Ryan L. Down syndrome and thyroid function in adults. Lancet. 1975 Oct 25;2(7939):794–796. doi: 10.1016/s0140-6736(75)80007-9. [DOI] [PubMed] [Google Scholar]
  2. Burgio G. R., Severi F., Rossoni R., Vaccaro R. Autoantibodies in Down's syndrome. Lancet. 1966 Feb 26;1(7435):497–498. doi: 10.1016/s0140-6736(66)91511-x. [DOI] [PubMed] [Google Scholar]
  3. Carter D. M., Jegasothy B. V. Alopecia areata and Down syndrome. Arch Dermatol. 1976 Oct;112(10):1397–1399. [PubMed] [Google Scholar]
  4. Coleman M., Abbassi V. Down's syndrome and hypothyroidism: coincidence or consequence? Lancet. 1984 Mar 10;1(8376):569–569. doi: 10.1016/s0140-6736(84)90972-3. [DOI] [PubMed] [Google Scholar]
  5. DONIACH D., NILSSON L. R., ROITT I. M. AUTOIMMUNE THYROIDITIS IN CHILDREN AND ADOLESCENTS. II. IMMUNOLOGICAL CORRELATIONS AND PARENT STUDY. Acta Paediatr Scand. 1965 May;54:260–274. doi: 10.1111/j.1651-2227.1965.tb06369.x. [DOI] [PubMed] [Google Scholar]
  6. Du Vivier A., Munro D. D. Alopecia areata, autoimmunity, and Down's syndrome. Br Med J. 1975 Jan 25;1(5951):191–192. doi: 10.1136/bmj.1.5951.191. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Fabris N., Mocchegiani E., Amadio L., Zannotti M., Licastro F., Franceschi C. Thymic hormone deficiency in normal ageing and Down's syndrome: is there a primary failure of the thymus? Lancet. 1984 May 5;1(8384):983–986. doi: 10.1016/s0140-6736(84)92325-0. [DOI] [PubMed] [Google Scholar]
  8. Fort P., Lifshitz F., Bellisario R., Davis J., Lanes R., Pugliese M., Richman R., Post E. M., David R. Abnormalities of thyroid function in infants with Down syndrome. J Pediatr. 1984 Apr;104(4):545–549. doi: 10.1016/s0022-3476(84)80544-2. [DOI] [PubMed] [Google Scholar]
  9. Gershwin M. E., Crinella F. M., Castles J. J., Trent J. K. Immunologic characteristics of Down's syndrome. J Ment Defic Res. 1977 Dec;21(4):237–249. doi: 10.1111/j.1365-2788.1977.tb01587.x. [DOI] [PubMed] [Google Scholar]
  10. Levin S., Schlesinger M., Handzel Z., Hahn T., Altman Y., Czernobilsky B., Boss J. Thymic deficiency in Down's syndrome. Pediatrics. 1979 Jan;63(1):80–87. [PubMed] [Google Scholar]
  11. Levo Y., Green P. Down's syndrome and autoimmunity. Am J Med Sci. 1977 Jan-Feb;273(1):95–99. doi: 10.1097/00000441-197701000-00010. [DOI] [PubMed] [Google Scholar]
  12. Lobo E. de H., Khan M., Tew J. Community study of hypothyroidism in Down's syndrome. Br Med J. 1980 May 24;280(6226):1253–1253. doi: 10.1136/bmj.280.6226.1253. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. McCulloch A. J., Ince P. G., Kendall-Taylor P. Autoimmune chronic active hepatitis in Down's syndrome. J Med Genet. 1982 Jun;19(3):232–234. doi: 10.1136/jmg.19.3.232. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Murdoch J. C., Ratcliffe W. A., McLarty D. G., Rodger J. C., Ratcliffe J. G. Thyroid function in adults with Down's syndrome. J Clin Endocrinol Metab. 1977 Mar;44(3):453–458. doi: 10.1210/jcem-44-3-453. [DOI] [PubMed] [Google Scholar]
  15. Sare Z., Ruvalcaba R. H., Kelley V. C. Prevalence of thyroid disorder in Down syndrome. Clin Genet. 1978 Sep;14(3):154–158. doi: 10.1111/j.1399-0004.1978.tb02121.x. [DOI] [PubMed] [Google Scholar]
  16. Strakosch C. R., Wenzel B. E., Row V. V., Volpé R. Immunology of autoimmune thyroid diseases. N Engl J Med. 1982 Dec 9;307(24):1499–1507. doi: 10.1056/NEJM198212093072407. [DOI] [PubMed] [Google Scholar]
  17. Vanhaelst L., Hayez F., Bonnyns M., Basteinie P. A. Thyroid auto-immune disease and thyroid function in families of subjects with Down's syndrome. J Clin Endocrinol Metab. 1970 Jun;30(6):792–797. doi: 10.1210/jcem-30-6-792. [DOI] [PubMed] [Google Scholar]
  18. WUNDERLICH C., BRAUN-FALCO O. MONGOLISMUS UND ALOPECIA AREATA. Med Welt. 1965 Mar 6;10:477–481. [PubMed] [Google Scholar]

Articles from Archives of Disease in Childhood are provided here courtesy of BMJ Publishing Group

RESOURCES