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. 1986 May;61(5):478–483. doi: 10.1136/adc.61.5.478

Respiratory tract disease in systemic lupus erythematosus.

J C de Jongste, H J Neijens, E J Duiverman, J M Bogaard, K F Kerrebijn
PMCID: PMC1777806  PMID: 3717994

Abstract

Respiratory tract involvement is common in adults with systemic lupus erythematosus (SLE). Although SLE in children usually follows a more severe course than in adults, there are few reports on pulmonary disease and lung function in children with SLE. We performed lung function tests and chest x ray examinations in eight children with SLE (mean age 11.1 years), three of whom presented with pulmonary symptoms. A high prevalence of lung involvement was found, including interstitial or localised infiltrations, pleural effusion, a restrictive impairment of lung function, and dysfunction of the diaphragm. Three patients required artificial ventilation. Two main mechanisms of ventilatory impairment seem to occur in children with SLE: firstly, acute interstitial pneumonia, which rapidly improves on treatment with steroids, and, secondly, restriction of lung volume, mainly due to respiratory muscle weakness.

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Selected References

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