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. 1987 Jun;62(6):580–584. doi: 10.1136/adc.62.6.580

Plasma thyrocalcitonin and parathyroid hormone concentrations in early neonatal hypocalcaemia.

C Romagnoli, E Zecca, G Tortorolo, A Diodato, G Fazzini, M Sorcini-Carta
PMCID: PMC1778412  PMID: 3619474

Abstract

During the first week of life serum calcium, phosphorus, magnesium, immunoreactive thyrocalcitonin hormone, and parathyroid hormone concentrations were determined daily in 36 preterm and 29 small for gestational age, full term, healthy infants. Preterm babies with early neonatal hypocalcaemia had significantly higher concentrations of serum thyrocalcitonin hormone in the first four days of life than normocalcaemic preterm babies. Parathyroid hormone concentrations were similar in hypocalcaemic and normocalcaemic infants. In contrast, in the full term group no significant differences were detected in thyrocalcitonin hormone and parathyroid hormone patterns between hypocalcaemic and normocalcaemic subjects. This suggests two different pathogeneses for early hypocalcaemia in low birthweight infants. Hyperthyrocalcitoninaemia seems to be the main determining factor in preterm infants, while a non-hormonal pathogenesis should be considered in full term infants who are small for gestational age.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. David L., Salle B. L., Putet G., Grafmeyer D. C. Serum immunoreactive calcitonin in low birth weight infants. Description of early changes; effect of intravenous calcium infusion; relationships with early changes in serum calcium, phosphorus, magnesium, parathyroid hormone, and gastrin levels. Pediatr Res. 1981 May;15(5):803–808. [PubMed] [Google Scholar]
  2. Dubowitz L. M., Dubowitz V., Goldberg C. Clinical assessment of gestational age in the newborn infant. J Pediatr. 1970 Jul;77(1):1–10. doi: 10.1016/s0022-3476(70)80038-5. [DOI] [PubMed] [Google Scholar]
  3. Hillman L. S., Rojanasathit S., Slatopolsky E., Haddad J. G. Serial measurements of serum calcium, magnesium, parathyroid hormone, calcitonin, and 25-hydroxy-vitamin D in premature and term infants during the first week of life. Pediatr Res. 1977 Jun;11(6):739–744. doi: 10.1203/00006450-197706000-00009. [DOI] [PubMed] [Google Scholar]
  4. LUBCHENCO L. O., HANSMAN C., DRESSLER M., BOYD E. INTRAUTERINE GROWTH AS ESTIMATED FROM LIVEBORN BIRTH-WEIGHT DATA AT 24 TO 42 WEEKS OF GESTATION. Pediatrics. 1963 Nov;32:793–800. [PubMed] [Google Scholar]
  5. Root A. W., Harrison H. E. Recent advances in calcium metabolism. II. Disorders of calcium homeostasis. J Pediatr. 1976 Feb;88(2):177–199. doi: 10.1016/s0022-3476(76)80981-x. [DOI] [PubMed] [Google Scholar]
  6. Salle B. L., David L., Chopard J. P., Grafmeyer D. C., Renaud H. Prevention of early neonatal hypocalcemia in low birth weight infants with continuous calcium infusion: effect on serum calcium, phosphorus, magnesium, and circulating immunoreactive parathyroid hormone and calcitonin. Pediatr Res. 1977 Dec;11(12):1180–1185. doi: 10.1203/00006450-197712000-00003. [DOI] [PubMed] [Google Scholar]
  7. Salle B. L., David L., Glorieux F. H., Delvin E., Senterre J., Renaud H. Early oral administration of vitamin D and its metabolites in premature neonates. Effect on mineral homeostasis. Pediatr Res. 1982 Jan;16(1):75–78. doi: 10.1203/00006450-198201001-00015. [DOI] [PubMed] [Google Scholar]
  8. Sann L., David L., Chayvialle J. A., Lasne Y., Bethenod M. Effect of early oral calcium supplementation on serum calcium and immunoreactive calcitonin concentration in preterm infants. Arch Dis Child. 1980 Aug;55(8):611–615. doi: 10.1136/adc.55.8.611. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Tsang R. C., Donovan E. F., Steichen J. J. Calcium physiology and pathology in the neonate. Pediatr Clin North Am. 1976 Nov;23(4):611–626. doi: 10.1016/s0031-3955(16)33348-x. [DOI] [PubMed] [Google Scholar]
  10. Tsang R. C., Light I. J., Sutherland J. M., Kleinman L. I. Possible pathogenetic factors in neonatal hypocalcemia of prematurity. The role of gestation, hyperphosphatemia, hypomagnesemia, urinary calcium loss, and parathormone responsiveness. J Pediatr. 1973 Mar;82(3):423–429. doi: 10.1016/s0022-3476(73)80115-5. [DOI] [PubMed] [Google Scholar]
  11. ZILVERSMIT D. B., DAVIS A. K. Microdetermination of plasma phospholipids by trichloroacetic acid precipitation. J Lab Clin Med. 1950 Jan;35(1):155–160. [PubMed] [Google Scholar]

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