Abstract
BCG vaccination has been routinely offered to infant Asian children in Birmingham since 1965. We conducted a case-control study to assess the protective effect of this scheme. Altogether 108 Asian children aged under 13 years, born since 1965, received treatment for tuberculosis. For each case four controls were selected; they were matched to the case by month and year of birth, sex, and ethnic origin. Cases and controls were all born in Birmingham. Of the cases, 62 out of 108 (57%) had received BCG, and of the controls, 336 out of 432 (78%) had received BCG. The estimated protective efficacy of vaccination was 64% (95% confidence limits, 43% and 77%). Routine BCG vaccination in infant Asians confers useful protection against the development of tuberculosis in childhood.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Clemens J. D., Chuong J. J., Feinstein A. R. The BCG controversy. A methodological and statistical reappraisal. JAMA. 1983 May 6;249(17):2362–2369. [PubMed] [Google Scholar]
- Curtis H. M., Leck I., Bamford F. N. Incidence of childhood tuberculosis after neonatal BCG vaccination. Lancet. 1984 Jan 21;1(8369):145–148. doi: 10.1016/s0140-6736(84)90072-2. [DOI] [PubMed] [Google Scholar]
- Grindulis H., Baynham M. I., Scott P. H., Thompson R. A., Wharton B. A. Tuberculin response two years after BCG vaccination at birth. Arch Dis Child. 1984 Jul;59(7):614–619. doi: 10.1136/adc.59.7.614. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lumb K. M., Bandaranayake R., Bevan P. J. BCG vaccination in infancy. Public Health. 1986 Jan;100(1):54–55. doi: 10.1016/s0033-3506(86)80088-9. [DOI] [PubMed] [Google Scholar]
- Miettinen O. S. Estimation of relative risk from individually matched series. Biometrics. 1970 Mar;26(1):75–86. [PubMed] [Google Scholar]
- Miettinen O. S. Proportion of disease caused or prevented by a given exposure, trait or intervention. Am J Epidemiol. 1974 May;99(5):325–332. doi: 10.1093/oxfordjournals.aje.a121617. [DOI] [PubMed] [Google Scholar]
- Miettinen O. Estimability and estimation in case-referent studies. Am J Epidemiol. 1976 Feb;103(2):226–235. doi: 10.1093/oxfordjournals.aje.a112220. [DOI] [PubMed] [Google Scholar]
- Padungchan S., Konjanart S., Kasiratta S., Daramas S., ten Dam H. G. The effectiveness of BCG vaccination of the newborn against childhood tuberculosis in Bangkok. Bull World Health Organ. 1986;64(2):247–258. [PMC free article] [PubMed] [Google Scholar]
- Smith P. G. Retrospective assessment of the effectiveness of BCG vaccination against tuberculosis using the case-control method. Tubercle. 1982 Mar;63(1):23–35. doi: 10.1016/s0041-3879(82)80006-8. [DOI] [PubMed] [Google Scholar]
- Sutherland I., Springett V. H. Effectiveness of BCG vaccination in England and Wales in 1983. Tubercle. 1987 Jun;68(2):81–92. doi: 10.1016/0041-3879(87)90023-7. [DOI] [PubMed] [Google Scholar]
- Tidjani O., Amedome A., ten Dam H. G. The protective effect of BCG vaccination of the newborn against childhood tuberculosis in an African community. Tubercle. 1986 Dec;67(4):269–281. doi: 10.1016/0041-3879(86)90016-4. [DOI] [PubMed] [Google Scholar]
- Young T. K., Hershfield E. S. A case-control study to evaluate the effectiveness of mass neonatal BCG vaccination among Canadian Indians. Am J Public Health. 1986 Jul;76(7):783–786. doi: 10.2105/ajph.76.7.783. [DOI] [PMC free article] [PubMed] [Google Scholar]
- ten Dam H. G., Hitze K. L. Does BCG vaccination protect the newborn and young infants? Bull World Health Organ. 1980;58(1):37–41. [PMC free article] [PubMed] [Google Scholar]