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. 1996 Oct;178(19):5790–5792. doi: 10.1128/jb.178.19.5790-5792.1996

The nucleoid protein H-NS facilitates chromosome DNA replication in Escherichia coli dnaA mutants.

T Katayama 1, M Takata 1, K Sekimizu 1
PMCID: PMC178422  PMID: 8824628

Abstract

Growth inhibition of the dnaA(Cs) mutant, which overinitiates chromosome replication, was shown to be dependent upon the nucleoid protein H-NS. [3H]thymine incorporation experiments indicated that the absence of H-NS inhibited overreplication by the dnaA(Cs) mutant. In addition, the temperature-sensitive phenotype of a dnaA46 mutant was enhanced by disruption of H-NS. These observations suggest that H-NS directly or indirectly facilitates the initiation of chromosome replication.

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Selected References

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