Abstract
A chemical method has been developed for estimating the acetylator phenotype without the use of special equipment. One urine specimen taken after ingestion of sulphadimidine, sulphapyridine, or sulphasalazine is required. The acetylator phenotype was assessed correctly in 150 urine specimens from 100 healthy subjects. Between 15 and 25 specimens can be determined hourly. Urine specimens for the test can be stored for two weeks at 37°C without any loss of drugs or their metabolites.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- EVANS D. A., WHITE T. A. HUMAN ACETYLATION POLYMORPHISM. J Lab Clin Med. 1964 Mar;63:394–403. [PubMed] [Google Scholar]
- Evans D. A. An improved and simplified method of detecting the acetylator phenotype. J Med Genet. 1969 Dec;6(4):405–407. doi: 10.1136/jmg.6.4.405. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Eze L. C., Evans D. A. The use of the autoanalyzer to determine the acetylator phenotype. J Med Genet. 1972 Mar;9(1):57–59. doi: 10.1136/jmg.9.1.57. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Gelber R., Peters J. H., Gordon G. R., Glazko A. J., Levy L. The polymorphic acetylation of dapsone in man. Clin Pharmacol Ther. 1971 Mar-Apr;12(2):225–238. doi: 10.1002/cpt1971122part1225. [DOI] [PubMed] [Google Scholar]
- Kutt H., Brennan R., Dehejia H., Verebely K. Diphenylhydantoin intoxication. A complication of isoniazid therapy. Am Rev Respir Dis. 1970 Mar;101(3):377–384. doi: 10.1164/arrd.1970.101.3.377. [DOI] [PubMed] [Google Scholar]
- Rao K. V., Mitchison D. A., Nair N. G., Prema K., Tripathy S. P. Sulphadimidine acetylation test for classification of patients as slow or rapid inactivators of isoniazid. Br Med J. 1970 Aug 29;3(5721):495–497. doi: 10.1136/bmj.3.5721.495. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Russell D. W. Simple method for determining isoniazid acetylator phenotype. Br Med J. 1970 Aug 8;3(5718):324–325. doi: 10.1136/bmj.3.5718.324. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Schröder H., Evans D. A. The polymorphic acetylation of sulphapyridine in man. J Med Genet. 1972 Jun;9(2):168–171. doi: 10.1136/jmg.9.2.168. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Tiitinen H. Isoniazid and ethionamide serum levels and inactivation in Finnish subjects. Scand J Respir Dis. 1969;50(2):110–124. [PubMed] [Google Scholar]