Abstract
Aqueous humour samples from untreated patients with acute anterior uveitis were found to contain substantial amounts of prostaglandin-like activity. Little activity was found in aqueous from patients treated with steroids, and none (<2 ng/ml) was detected in aqueous from the uninflamed eyes of patients with cataract. Alkaline hydrolysis of the samples from inflamed eyes suggested the presence of both E and F prostaglandin-like activity. These results show that prostaglandins may be involved in acute anterior uveitis.
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Selected References
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- Ambache N. P., Brummer H. C. A simple chemical procedure for distinguishing E from F prostaglandins, with application to tissue extracts. Br J Pharmacol Chemother. 1968;33:162–170. [PMC free article] [PubMed] [Google Scholar]
- Beitch B. R., Eakins K. E. The effects of prostaglandins on the intraocular pressure of the rabbit. Br J Pharmacol. 1969 Sep;37(1):158–167. doi: 10.1111/j.1476-5381.1969.tb09533.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Eakins K. E. Increased intraocular pressure produced by prostaglandins E1 and E2 in the cat eye. Exp Eye Res. 1970 Jul;10(1):87–92. doi: 10.1016/s0014-4835(70)80014-8. [DOI] [PubMed] [Google Scholar]
- Greaves M. W., Sondergaard J., McDonald-Gibson W. Recovery of prostaglandins in human cutaneous inflammation. Br Med J. 1971 May 1;2(5756):258–260. doi: 10.1136/bmj.2.5756.258. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kelly R. G., Starr M. S. Effects of prostaglandins and a prostaglandin antagonist on intraocular pressure and protein in the monkey eye. Can J Ophthalmol. 1971 Jul;6(3):205–211. [PubMed] [Google Scholar]
- Starr M. S. Further studies on the effect of prostaglandin on intraocular pressure in the rabbit. Exp Eye Res. 1971 Mar;11(2):170–177. doi: 10.1016/s0014-4835(71)80020-9. [DOI] [PubMed] [Google Scholar]
- Unger W. G., Stamford I. F., Bennett A. Extraction of prostaglandins from human blood. Nature. 1971 Oct 1;233(5318):336–337. doi: 10.1038/233336b0. [DOI] [PubMed] [Google Scholar]
- VANE J. R. A sensitive method for the assay of 5-hydroxytryptamine. Br J Pharmacol Chemother. 1957 Sep;12(3):344–349. doi: 10.1111/j.1476-5381.1957.tb00146.x. [DOI] [PMC free article] [PubMed] [Google Scholar]