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. 1972 Dec 30;4(5843):757–759. doi: 10.1136/bmj.4.5843.757

Permanent Neurological Sequelae Despite Haemodialysis for Lithium Intoxication

B von Hartitzsch, N A Hoenich, R J Leigh, R Wilkinson, T H Frost, A Weddel, G A Posen
PMCID: PMC1787044  PMID: 4646505

Abstract

Three patients with lithium toxicity are reported, two of whom were exposed to toxic lithium levels for a prolonged period: both survived with permanent damage to basal ganglia and cerebellar connexions despite effective lowering of lithium levels by haemodialysis. Data obtained during dialysis treatment show prolonged haemodialysis to be the treatment of choice. If facilities for haemodialysis are not available or the patient presents with toxic lithium levels and minimal symptoms peritoneal dialysis will effectively lower serum lithium levels, but more slowly than haemodialysis.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Baastrup P. C., Poulsen J. C., Schou M., Thomsen K., Amdisen A. Prophylactic lithium: double blind discontinuation in manic-depressive and recurrent-depressive disorders. Lancet. 1970 Aug 15;2(7668):326–330. doi: 10.1016/s0140-6736(70)92870-9. [DOI] [PubMed] [Google Scholar]
  2. Baastrup P. C., Schou M. Lithium as a prophylactic agents. Its effect against recurrent depressions and manic-depressive psychosis. Arch Gen Psychiatry. 1967 Feb;16(2):162–172. doi: 10.1001/archpsyc.1967.01730200030005. [DOI] [PubMed] [Google Scholar]
  3. Coppen A., Noguera R., Bailey J., Burns B. H., Swani M. S., Hare E. H., Gardner R., Maggs R. Prophylactic lithium in affective disorders. Controlled trial. Lancet. 1971 Aug 7;2(7719):275–279. doi: 10.1016/s0140-6736(71)91331-6. [DOI] [PubMed] [Google Scholar]
  4. Schou M., Amdisen A., Trap-Jensen J. Lithium poisoning. Am J Psychiatry. 1968 Oct;125(4):520–527. doi: 10.1176/ajp.125.4.520. [DOI] [PubMed] [Google Scholar]
  5. Schou M., Baastrup P. C. Lithium treatment of manic-depressive disorder. Dosage and control. JAMA. 1967 Aug 28;201(9):696–698. [PubMed] [Google Scholar]
  6. Wharton R. N., Fieve R. R. The use of lithium in the affective psychoses. Am J Psychiatry. 1966 Dec;123(6):706–712. doi: 10.1176/ajp.123.6.706. [DOI] [PubMed] [Google Scholar]
  7. Zall H., Therman P. G., Myers J. M. Lithium carbonate: a clinical study. Am J Psychiatry. 1968 Oct;125(4):549–555. doi: 10.1176/ajp.125.4.549. [DOI] [PubMed] [Google Scholar]

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