Abstract
The pharmacological phenomena of enhancement and potentiation of uterine response occur respectively when combinations of some prostaglandins and oxytocin are given serially and simultaneously to a patient. Employing these phenomena allows small doses of the drugs to achieve the same effects as a large dose given alone. In a pilot study of the use of the combination of prostaglandin and oxytocin for the induction of mid-trimester abortion seven of nine women were aborted within 48 hours. Side effects attributable to prostaglandin were eliminated or reduced in severity.
Full text
PDFImages in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- BURNHILL M. S., GAINES J. A., GUTTMACHER A. F. Concentrated oxytocin solution for therapeutic interruption of midtrimester pregnancy. A preliminary report. Obstet Gynecol. 1962 Jul;20:94–100. doi: 10.1097/00006250-196207000-00013. [DOI] [PubMed] [Google Scholar]
- Brummer H. C. Interaction of E prostaglandins and syntocinon on the pregnant human myometrium. J Obstet Gynaecol Br Commonw. 1971 Apr;78(4):305–309. doi: 10.1111/j.1471-0528.1971.tb00277.x. [DOI] [PubMed] [Google Scholar]
- Clegg P. C., Hall W. J., Pickles V. R. The action of ketonic prostaglandins on the guinea-pig myometrium. J Physiol. 1966 Mar;183(1):123–144. doi: 10.1113/jphysiol.1966.sp007855. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Gillespie A., Beazley J. M., van Dorp D. A. The use of an "unnatural" prostaglandin in the termination of pregnancy. J Obstet Gynaecol Br Commonw. 1971 Apr;78(4):301–304. doi: 10.1111/j.1471-0528.1971.tb00276.x. [DOI] [PubMed] [Google Scholar]
- Karim S. M., Filshie G. M. Therapeutic abortion using prostaglandin F2alpha. Lancet. 1970 Jan 24;1(7639):157–159. doi: 10.1016/s0140-6736(70)90402-2. [DOI] [PubMed] [Google Scholar]
- Karim S. M., Filshie G. M. Use of prostaglandin E2 for therapeutic abortion. Br Med J. 1970 Jul 25;3(5716):198–200. doi: 10.1136/bmj.3.5716.198. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Wiqvist N., Bygdeman M. Therapeutic abortion by local administration of prostaglandin. Lancet. 1970 Oct 3;2(7675):716–717. doi: 10.1016/s0140-6736(70)91978-1. [DOI] [PubMed] [Google Scholar]