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. 1972 Feb 19;1(5798):477–479. doi: 10.1136/bmj.1.5798.477

Measles Virus Antibody in Cerebrospinal Fluids from Patients with Multiple Sclerosis

A A Salmi, M Panelius, P Halonen, U K Rinne, K Penttinen
PMCID: PMC1787490  PMID: 4621451

Abstract

A strong measles-specific gel precipitation reaction was found in the cerebrospinal fluid (C.S.F.) of two patients with multiple sclerosis (M.S.) (total of 15 tested). The serum and C.S.F. specimens from these two patients were tested for measles antibody by six assay methods. The results were compared with those obtained from serum and C.S.F. specimens of a patient with subacute sclerosing panencephalitis (S.S.P.E.). The gel precipitation line produced by the C.S.F. from the M.S. patients was identical with one of the three lines produced by the C.S.F. from the S.S.P.E. patient. The main antigenic component responsible for measles antibody appearing in the C.S.F. of the S.S.P.E. patient and the M.S. patients was also electrophoretically similar, and the corresponding antibody was associated with IgG. The serum/C.S.F. antibody titre ratios with the various assay methods used suggest that the C.S.F. antibodies are mainly to other than envelope components of measles virus. No complement-fixing antibody against 27 other viruses or Mycoplasma pneumoniae was found in the C.S.F. of the two M.S. patients.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ADAMS J. M., IMAGAWA D. T. Measles antibodies in multiple sclerosis. Proc Soc Exp Biol Med. 1962 Dec;111:562–566. doi: 10.3181/00379727-111-27855. [DOI] [PubMed] [Google Scholar]
  2. Adams J. M. Measles antibodies in patients with multiple sclerosis. Neurology. 1967 Jul;17(7):707–passim. doi: 10.1212/wnl.17.7.707. [DOI] [PubMed] [Google Scholar]
  3. Brown P., Cathala F., Gajdusek D. C., Gibbs C. J., Jr Measles antibodies in the cerebrospinal fluid of patients with multiple sclerosis. Proc Soc Exp Biol Med. 1971 Jul;137(3):956–961. doi: 10.3181/00379727-137-35704. [DOI] [PubMed] [Google Scholar]
  4. Clarke J. K., Dane D. S., Dick G. W. Viral antibody in the cerebrospinal fluid and serum of multiple sclerosis patients. Brain. 1965 Dec;88(5):953–962. doi: 10.1093/brain/88.5.953. [DOI] [PubMed] [Google Scholar]
  5. Cohen S., Bannister R. Immunoglobulin synthesis within the central nervous system in disseminated sclerosis. Lancet. 1967 Feb 8;1(7486):366–367. doi: 10.1016/s0140-6736(67)92900-5. [DOI] [PubMed] [Google Scholar]
  6. Connolly J. H., Allen I. V., Hurwitz L. J., Millar J. H. Measles-virus antibody and antigen in subacute sclerosing panencephalitis. Lancet. 1967 Mar 11;1(7489):542–544. doi: 10.1016/s0140-6736(67)92117-4. [DOI] [PubMed] [Google Scholar]
  7. Cutler R. W., Merler E., Hammerstad J. P. Production of antibody by the central nervous system in subacute sclerosing panencephalitis. Neurology. 1968 Jan;18(1 Pt 2):129–132. doi: 10.1212/wnl.18.1_part_2.129. [DOI] [PubMed] [Google Scholar]
  8. Link H., Müller R. Immunoglobulins in multiple sclerosis and infections of the nervous system. Arch Neurol. 1971 Oct;25(4):326–344. doi: 10.1001/archneur.1971.00490040052007. [DOI] [PubMed] [Google Scholar]
  9. Panelius M., Salmi A. A., Halonen P., Penttinen K. Measles antibodies detected with various techniques in sera of patients with multiple sclerosis. Acta Neurol Scand. 1971;47(3):315–330. doi: 10.1111/j.1600-0404.1971.tb07486.x. [DOI] [PubMed] [Google Scholar]
  10. Panelius M., Salmi A., Halonen P. Gel precipitation reactions between measles antigens and sera of patients with multiple sclerosis. Acta Pathol Microbiol Scand B Microbiol Immunol. 1970;78(5):588–592. doi: 10.1111/j.1699-0463.1970.tb04345.x. [DOI] [PubMed] [Google Scholar]
  11. Penttinen K., Myllylä G. Interaction in human blood platelets, viruses and antibodies. I. Platelet aggregation test with microequipment. Ann Med Exp Biol Fenn. 1968;46(2):188–192. [PubMed] [Google Scholar]
  12. REED D., SEVER J., KURTZKE J., KURLAND L. MEASLES ANTIBODY IN PATIENTS WITH MULTIPLE SCLEROSIS. Arch Neurol. 1964 Apr;10:402–410. doi: 10.1001/archneur.1964.00460160072007. [DOI] [PubMed] [Google Scholar]
  13. SEVER J. L. Application of a microtechnique to viral serological investigations. J Immunol. 1962 Mar;88:320–329. [PubMed] [Google Scholar]
  14. SIBLEY W. A., FOLEY J. M. MEASLES ANTIBODIES IN MULTIPLE SCLEROSIS. Trans Am Neurol Assoc. 1963;88:277–281. [PubMed] [Google Scholar]
  15. Salmi A. A. Gel precipitation reactions between alkaline extracted rubella antigens and human sera. Acta Pathol Microbiol Scand. 1969;76(2):271–278. doi: 10.1111/j.1699-0463.1969.tb03257.x. [DOI] [PubMed] [Google Scholar]
  16. Schluederberg A., Nakamura M. A salt-dependent hemagglutinating particle from measles-infected cells. Virology. 1967 Oct;33(2):297–306. doi: 10.1016/0042-6822(67)90148-1. [DOI] [PubMed] [Google Scholar]

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