Abstract
Addition to tobacco of phenylmethyloxadiazole (PMO) protects rats against some of the adverse effects of exposure to cigarette smoke. Two groups of 15 rats were exposed to 25 cigarettes a day for 24 days; the group whose cigarette included PMO showed less immediate distress after exposure, a smaller tracheal goblet cell count, less thickening of the tracheal epithelium, and less cells in mitosis than those exposed to ordinary tobacco.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Dalhamn T. Inhibition of the ciliostatic effect of cigarette smoke by oxolamine citrate. Am Rev Respir Dis. 1966 Nov;94(5):799–800. doi: 10.1164/arrd.1966.94.5.799. [DOI] [PubMed] [Google Scholar]
- FREEMAN G., HAYDON G. B. EMPHYSEMA AFTER LOW-LEVEL EXPOSURE TO NO2. Arch Environ Health. 1964 Jan;8:125–128. doi: 10.1080/00039896.1964.10663640. [DOI] [PubMed] [Google Scholar]
- Jones R., Baetjer A. M., Reid L. Effect of extremes of temperature and humidity on the goblet cell count in the rat airway epithelium. Br J Ind Med. 1971 Oct;28(4):369–373. doi: 10.1136/oem.28.4.369. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lamb D., Reid L. Mitotic rates, goblet cell increase and histochemical changes in mucus in rat bronchial epithelium during exposure to sulphur dioxide. J Pathol Bacteriol. 1968 Jul;96(1):97–111. doi: 10.1002/path.1700960111. [DOI] [PubMed] [Google Scholar]
- Passey R. D., Blackmore M., Warbrick-Smith D., Jones R. Smoking risks of different tobaccos. Br Med J. 1971 Oct 23;4(5781):198–201. doi: 10.1136/bmj.4.5781.198. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Reid L. Evaluation of model systems for study of airway epithelium, cilia, and mucus. Arch Intern Med. 1970 Sep;126(3):428–434. [PubMed] [Google Scholar]
- WILHELM D. L. Regeneration of tracheal epithelium. J Pathol Bacteriol. 1953 Apr;65(2):543–550. doi: 10.1002/path.1700650226. [DOI] [PubMed] [Google Scholar]