Abstract
In a double-blind between-patient study of aspirin and benorylate carried out in 72 outpatients with rheumatoid arthritis, benorylate 4 g twice daily was shown to be an effective analgesic and anti-inflammatory drug, its effects being indistinguishable from those of aspirin 1·2 g four times daily. Compared with the pretreatment values both drugs produced a statistically significant improvement (P < 0·01) in functional grade, overall pain, articular index, and grip strength at the end of the first and second weeks. The overall incidence of side effects was less with benorylate, though this difference was not significant at the 5% level.
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Selected References
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- Boardman P. L., Hart F. D. Clinical measurement of the anti-inflammatory effects of salicylates in rheumatoid arthritis. Br Med J. 1967 Nov 4;4(5574):264–268. doi: 10.1136/bmj.4.5574.264. [DOI] [PMC free article] [PubMed] [Google Scholar]
- CROMIE B. W. THE FEET OF CLAY OF THE DOUBLE-BLIND TRIAL. Lancet. 1963 Nov 9;2(7315):994–997. doi: 10.1016/s0140-6736(63)90693-7. [DOI] [PubMed] [Google Scholar]
- Hart F. D., Huskisson E. C. Measurement in rheumatoid arthritis. Lancet. 1972 Jan 1;1(7740):28–30. doi: 10.1016/s0140-6736(72)90015-3. [DOI] [PubMed] [Google Scholar]
- Ingpen M. L., Kendall P. H. A simple apparatus for assessment of stiffness. Ann Phys Med. 1968 Feb;9(5):203–205. doi: 10.1093/rheumatology/9.5.203. [DOI] [PubMed] [Google Scholar]
- Ingpen M. L. The quantitative measurement of joint changes in rheumatoid arthritis. Ann Phys Med. 1968 Nov;9(8):322–327. doi: 10.1093/rheumatology/9.8.322. [DOI] [PubMed] [Google Scholar]
- Rosner I., Malhie P., Mottot G. Pharmacologie du 4-(acétamido) phényl 2-acétoxybenzoate (Win 11450) Therapie. 1968 May-Jun;23(3):525–534. [PubMed] [Google Scholar]