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. 1972 Jul 15;3(5819):133–136. doi: 10.1136/bmj.3.5819.133

Incidence of Ocular Complications in Patients Undergoing Renal Transplantation

R Porter, A L Crombie, P S Gardner, R P Uldall
PMCID: PMC1788625  PMID: 4339112

Abstract

The eyes of 39 patients who had received allogenic renal transplants were examined for signs of disease. Nine (23%) had early posterior subcapsular cataracts, two (5%) developed acute cytomegalovirus retinitis, and one developed steroid-induced glaucoma. The lesions which were found were all attributable to the immunosuppressive drug therapy. Thirty-five (87%) had detectable complement-fixing antibodies to cytomegalovirus.

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Selected References

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  1. Armstrong D., Balakrishnan S. L., Steger L., Yu B., Stenzel K. H. Cytomegalovirus infections with viremia following renal transplantation. Arch Intern Med. 1971 Jan;127(1):111–115. [PubMed] [Google Scholar]
  2. BLACK R. L., OGLESBY R. B., VON SALLMANN L., BUNIM J. J. Posterior subcapsular cataracts induced by corticosteroids in patients with rheumatoid arthritis. JAMA. 1960 Sep 10;174:166–171. doi: 10.1001/jama.1960.63030020005014. [DOI] [PubMed] [Google Scholar]
  3. Bossen E. H., Johnston W. W., Amatulli J., Rowlands D. T., Jr Exfoliative cytopathologic studies in organ transplantation. I. The cytologic diagnosis of cytomegalic inclusion disease in the urine of renal allograft recipients. Am J Clin Pathol. 1969 Sep;52(3):340–344. doi: 10.1093/ajcp/52.3.340. [DOI] [PubMed] [Google Scholar]
  4. Burde R. M., Becker B. Corticosteroid-induced glaucoma and cataracts in contact lens wearers. JAMA. 1970 Sep 21;213(12):2075–2077. [PubMed] [Google Scholar]
  5. Craighead J. E., Hanshaw J. B., Carpenter C. B. Cytomegalovirus infection after renal allotransplantation. JAMA. 1967 Sep 4;201(10):725–728. [PubMed] [Google Scholar]
  6. De Venecia G., Zu Rhein G. M., Pratt M. V., Kisken W. Cytomegalic inclusion retinitis in an adult. Arch Ophthalmol. 1971 Jul;86(1):44–57. doi: 10.1001/archopht.1971.01000010046010. [DOI] [PubMed] [Google Scholar]
  7. Diosi P., Moldovan E., Tomescu N. Latent cytomegalovirus infection in blood donors. Br Med J. 1969 Dec 13;4(5684):660–662. doi: 10.1136/bmj.4.5684.660. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. GILES C. L., MASON G. L., DUFF I. F., McLEAN J. A. The association of cataract formation and systemic corticosteroid therapy. JAMA. 1962 Nov 17;182:719–722. doi: 10.1001/jama.1962.03050460011003. [DOI] [PubMed] [Google Scholar]
  9. GOLDMANN H. Cortisone glaucoma. Arch Ophthalmol. 1962 Nov;68:621–626. doi: 10.1001/archopht.1962.00960030625009. [DOI] [PubMed] [Google Scholar]
  10. HARRIS J. L. Glaucoma associated with steroid therapy and atopic dermatitis. Am J Ophthalmol. 1960 Feb;49:351–353. doi: 10.1016/0002-9394(60)91529-4. [DOI] [PubMed] [Google Scholar]
  11. HEDLEY-WHYTE E. T., CRAIGHEAD J. E. REPORT OF A CASE WITH ISOLATION OF VIRUS. N Engl J Med. 1965 Mar 4;272:473–475. doi: 10.1056/NEJM196503042720907. [DOI] [PubMed] [Google Scholar]
  12. Kanich R. E., Craighead J. E. Cytomegalovirus infection and cytomegalic inclusion disease in renal homotransplant recipients. Am J Med. 1966 Jun;40(6):874–882. doi: 10.1016/0002-9343(66)90202-6. [DOI] [PubMed] [Google Scholar]
  13. Käriäinen L., Klemola E., Paloheimo J. Rise of cytomegalovirus antibodies in an infectious-mononucleosis-like syndrome after transfusion. Br Med J. 1966 May 21;1(5498):1270–1272. doi: 10.1136/bmj.1.5498.1270. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Lang D. J., Hanshaw J. B. Cytomegalovirus infection and the postperfusion syndrome. Recognition of primary infections in four patients. N Engl J Med. 1969 May 22;280(21):1145–1149. doi: 10.1056/NEJM196905222802103. [DOI] [PubMed] [Google Scholar]
  15. Lang D. J., Scolnick E. M., Willerson J. T. Association of cytomegalovirus infection with the postperfusion syndrome. N Engl J Med. 1968 May 23;278(21):1147–1149. doi: 10.1056/NEJM196805232782105. [DOI] [PubMed] [Google Scholar]
  16. Paloheimo J. A., von Essen R., Klemola E., Käriäinen L., Siltanen P. Subclinical cytomegalovirus infections and cytomegalovirus mononculeosis after open heart surgery. Am J Cardiol. 1968 Nov;22(5):624–630. doi: 10.1016/0002-9149(68)90198-7. [DOI] [PubMed] [Google Scholar]
  17. Rifkind D., Goodman N., Hill R. B., Jr The clinical significance of cytomegalovirus infection in renal transplant recipients. Ann Intern Med. 1967 Jun;66(6):1116–1128. doi: 10.7326/0003-4819-66-6-1116. [DOI] [PubMed] [Google Scholar]
  18. Rifkind D. The activation of varicella-zoster virus infections by immunosuppressive therapy. J Lab Clin Med. 1966 Sep;68(3):463–474. [PubMed] [Google Scholar]
  19. SMITH M. E. RETINAL INVOLVEMENT IN ADULT CYTOMEGALIC INCLUSION DISEASE. Arch Ophthalmol. 1964 Jul;72:44–49. doi: 10.1001/archopht.1964.00970020046011. [DOI] [PubMed] [Google Scholar]
  20. STERN H., ELEK S. D. THE INCIDENCE OF INFECTION WITH CYTOMEGALOVIRUS IN A NORMAL POPULATION. A SEROLOGICAL STUDY IN GREATER LONDON. J Hyg (Lond) 1965 Mar;63:79–87. doi: 10.1017/s0022172400044983. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Stevens D. P., Barker L. F., Ketcham A. S., Meyer H. M., Jr Asymptomatic cytomegalovirus infection following blood transfusion in tumor surgery. JAMA. 1970 Feb 23;211(8):1341–1344. [PubMed] [Google Scholar]
  22. WONG T. W., WARNER N. E. Cytomegalic inclusion disease in adults. Report of 14 cases with review of literature. Arch Pathol. 1962 Nov;74:403–422. [PubMed] [Google Scholar]
  23. Williamson J., Paterson R. W., McGavin D. D., Jasani M. K., Boyle J. A., Doig W. M. Posterior subcapsular cataracts and glaucoma associated with long-term oral corticosteroid therapy. In patients with rheumatoid arthritis and related conditions. Br J Ophthalmol. 1969 Jun;53(6):361–372. doi: 10.1136/bjo.53.6.361. [DOI] [PMC free article] [PubMed] [Google Scholar]

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