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. 1972 Apr 1;2(5804):21–24. doi: 10.1136/bmj.2.5804.21

Outpatient Treatment Trial of Mild and Severe Hypertension

K L Stuart, C MacIver, J A Nicholson
PMCID: PMC1789009  PMID: 4552591

Abstract

Not much is known about the feasibility or the advantages of treatment of subjects with only mild hypertension. There are also many unresolved problems in the outpatient management of hypertension of any severity. In this study an analysis is made of the results of a controlled treatment trial of 56 subjects with mild hypertension, 26 of whom were treated with active drug and 30 initially with placebo, and a treatment programme involving 81 patients with moderate or severe hypertension, all of whom received treatment with active drug. The drugs used in this study were bethanidine, debrisoquine, and guanethidine.

Follow-up for 12 months or more was achieved in 87% of individuals admitted to the study with mild hypertension and in 80% with severe hypertension. Many subjects with only mildly raised blood pressure were found to have cardiac enlargement on chest x-ray (up to 45%) and left ventricular hypertrophy on electrocardiogram (up to 51%). Rapid rates of rise of blood pressure were observed in many placebo-treated subjects; but good blood pressure control was achieved in 63 out of 104 patients (61%) receiving active drug in both the mild and the severe hypertension groups. The drugs used showed approximately equal effectiveness in controlling blood pressure.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Athanassiadis D., Cranston W. I., Juel-Jensen B. E., Oliver D. O. Clinical observations on the effects of debrisoquine sulphate in patients with high blood-pressure. Br Med J. 1966 Sep 24;2(5516):732–735. doi: 10.1136/bmj.2.5516.732. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Bath J., Pickering D., Turner R. Clinical experience with bethanidine in treatment of hypertension. Br Med J. 1967 Dec 2;4(5578):519–521. doi: 10.1136/bmj.4.5578.519. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. DOLLERY C. T., EMSLIE-SMITH D., MILNE M. D. Clinical and pharmacological studies with guanethidine in the treatment of hypertension. Lancet. 1960 Aug 20;2(7147):381–387. doi: 10.1016/s0140-6736(60)92836-1. [DOI] [PubMed] [Google Scholar]
  4. Evans J. G., Rose G. Hypertension. Br Med Bull. 1971 Jan;27(1):37–42. doi: 10.1093/oxfordjournals.bmb.a070812. [DOI] [PubMed] [Google Scholar]
  5. JOHNSTON A. W., PRICHARD B. N., ROSENTHEIM M. L. THE USE OF BETHANIDINE IN THE TREATMENT OF HYPERTENSION. Lancet. 1964 Sep 26;2(7361):659–661. doi: 10.1016/s0140-6736(64)92475-4. [DOI] [PubMed] [Google Scholar]
  6. LOWTHER C. P., TURNER R. W. GUANETHIDINE IN THE TREATMENT OF HYPERTENSION. Br Med J. 1963 Sep 28;2(5360):776–781. doi: 10.1136/bmj.2.5360.776. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. MIALL W. E., KASS E. H., LING J., STUART K. L. Factors influencing arterial pressure in the general population in Jamaica. Br Med J. 1962 Aug 25;2(5303):497–506. doi: 10.1136/bmj.2.5303.497. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Miall W. E., Lovell H. G. Relation between change of blood pressure and age. Br Med J. 1967 Jun 10;2(5553):660–664. doi: 10.1136/bmj.2.5553.660. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Paul O. Risks of mild hypertension: a ten-year report. Br Heart J. 1971;33(Suppl):116–121. doi: 10.1136/hrt.33.suppl.116. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Prichard B. N., Johnston A. W., Hill I. D., Rosenheim M. L. Bethanidine, Guanethidine, and Methyldopa in Treatment of Hypertension: a Within-patient Comparison. Br Med J. 1968 Jan 20;1(5585):135–144. doi: 10.1136/bmj.1.5585.135. [DOI] [PMC free article] [PubMed] [Google Scholar]

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