Abstract
A very high incidence of posterior paresis in growing calves was casued by abnormal development of the vertebral column. The pathological changes were focal premature synostoses of vertebral growth plates with resulting reduction in size of the vertebral canal. Malacic changes were seen in sections from all areas of the spinal cord. Abnormalities in growth of the cranium and appendicular skeleton were also present. The growth plates in the cranial base were prematurely closed and the cranial cavity was shortened. Long bones were shortened and distorted. Possible causes include teratogenic plants or chemicals, mineral deficiencies, and hypervitaminosis A.
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- Dobson K. J. Osteodystrophy associated with hypervitaminosis A in growing pigs. Aust Vet J. 1969 Dec;45(12):570–573. doi: 10.1111/j.1751-0813.1969.tb16093.x. [DOI] [PubMed] [Google Scholar]
- Greene H. J., Leipold H. W., Huston K. Bovine congenital skeletal defects. Zentralbl Veterinarmed A. 1974 Nov;21(10):789–796. doi: 10.1111/j.1439-0442.1974.tb01339.x. [DOI] [PubMed] [Google Scholar]
- Grey R. M., Nielsen S. W., Rousseau J. E., Jr, Calhoun M. C., Eaton H. D. Pathology of skull, radius and rib in hypervitaminosis A of young calves. Pathol Vet. 1965;2(5):446–467. doi: 10.1177/030098586500200502. [DOI] [PubMed] [Google Scholar]
- Keeler R. F. Effect of natural teratogens in poisonous plants on fetal development in domestic animals. Adv Exp Med Biol. 1972;27:107–125. doi: 10.1007/978-1-4684-3219-0_10. [DOI] [PubMed] [Google Scholar]
- Lindsay F. E. Observations on the loci of ossification in the prenatal and neonatal bovine skeleton. 3. The vertebral column. Br Vet J. 1972 Mar;128(3):121–128. doi: 10.1016/s0007-1935(17)37083-5. [DOI] [PubMed] [Google Scholar]
- PEASE C. N. Focal retardation and arrestment of growth of bones due to vitamin A intoxication. JAMA. 1962 Dec 8;182:980–985. doi: 10.1001/jama.1962.03050490004002. [DOI] [PubMed] [Google Scholar]
- Pryor W. J., Seawright A. A., McCosker P. J. Hypervitaminosis A in the pig. Aust Vet J. 1969 Dec;45(12):563–569. doi: 10.1111/j.1751-0813.1969.tb16092.x. [DOI] [PubMed] [Google Scholar]
- Wolke R. E., Eaton H. D., Nielsen S. W., Helmboldt C. F. Qualitative and quantitative osteoblastic activity in chronic porcine hypervitaminosis A. J Pathol. 1969 Apr;97(4):677–686. doi: 10.1002/path.1710970413. [DOI] [PubMed] [Google Scholar]
- Wolke R. E., Nielsen S. W., Rousseau J. E., Jr Bone lesions of hypervitaminosis A in the pig. Am J Vet Res. 1968 May;29(5):1009–1024. [PubMed] [Google Scholar]