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. 1983 Jan;24(1):10–19.

Vaccination: Is it Effective in Preventing Respiratory Disease or Influencing Weight Gains in Feedlot Calves?

S W Martin
PMCID: PMC1790242  PMID: 17422213

Abstract

Respiratory disease, both undifferentiated and etiologically defined, remains a major problem in feedlot cattle. Vaccination has been used in an attempt to reduce the frequency and/or severity of respiratory disease in the first few weeks after the cattle arrive at the feedlot.

The efficacy of vaccination has been studied both in controlled laboratory experiments and field trials as well as observational studies. (In this review, efficacy refers to the ability to reduce overall treatment rate and/or increase weight gains.) This review summarizes the data resulting from studies of vaccine efficacy.

In general, there is little published data to support the use of vaccines against respiratory disease under feedlot conditions. Treatment rates and weight gains usually did not differ between vaccinated and nonvaccinated groups. The use of live bovine virus diarrhea virus vaccines was associated with a significant subsequent increase in treatment rates. Criteria to be considered in future field trials are described.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Boyland C. G., Lawson K. F. Letter to the editor: Infectious bovine rhinotracheitis. Can Vet J. 1975 May;16(5):148–148. [PMC free article] [PubMed] [Google Scholar]
  2. Curtis R. A., Angulo A. A field trial to evaluate an intranasal infectious bovine rhinotracheitis vaccine. Can Vet J. 1974 Nov;15(11):327–330. [PMC free article] [PubMed] [Google Scholar]
  3. Curtis R. A. Letter to the editor: A field trial to evaluate an intranasal infectious bovine rhinotracheitis vaccine. Can Vet J. 1975 Sep;16(9):274–274. [PMC free article] [PubMed] [Google Scholar]
  4. Frank G. H., Marshall R. G. Relationship of serum and nasal secretion-neutralizing antibodies in protection of calves against parainfluenza-3 virus. Am J Vet Res. 1971 Nov;32(11):1707–1713. [PubMed] [Google Scholar]
  5. Frank G. H., Marshall R. G., Smith P. C. Clinical and immunologic responses of cattle to infectious bovine rhinotracheitis virus after infection by viral aerosol or intramuscular inoculation. Am J Vet Res. 1977 Oct;38(10):1497–1502. [PubMed] [Google Scholar]
  6. Friend S. C., Wilkie B. N., Thomson R. G., Barnum D. A. Bovine pneumonic pasteurellosis: experimental induction in vaccinated and nonvaccinated calves. Can J Comp Med. 1977 Jan;41(1):77–83. [PMC free article] [PubMed] [Google Scholar]
  7. Gutekunst D. E., Paton I. M., Volenec F. J. Parainfluenza-3 vaccine in cattle: comparative efficacy of intranasal and intramuscular routes. J Am Vet Med Assoc. 1969 Dec 15;155(12):1879–1885. [PubMed] [Google Scholar]
  8. HAMDY A. H., TRAPP A. L. EXPERIMENTAL IMMUNIZATION OF CATTLE AGAINST SHIPPING FEVER. Cornell Vet. 1964 Jan;54:41–49. [PubMed] [Google Scholar]
  9. HAMDY A. H., TRAPP A. L. IMMUNIZATION OF CATTLE AGAINST SHIPPING FEVER: EXPERIMENTAL EXPOSURE. Am J Vet Res. 1964 Nov;25:1648–1652. [PubMed] [Google Scholar]
  10. HILL A. B. The clinical trial. N Engl J Med. 1952 Jul 24;247(4):113–119. doi: 10.1056/NEJM195207242470401. [DOI] [PubMed] [Google Scholar]
  11. Janzen E. D., Smart J. N., Nicholson H. H. Observations on an outbreak of infectious bovine rhinotracheitis in a bull test station. Can Vet J. 1980 Jan;21(1):24–27. [PMC free article] [PubMed] [Google Scholar]
  12. Jensen R., Pierson R. E., Braddy P. M., Saari D. A., Lauerman L. H., England J. J., Keyvanfar H., Collier J. R., Horton D. P., McChesney A. E. Shipping fever pneumonia in yearling feedlot cattle. J Am Vet Med Assoc. 1976 Sep 1;169(5):500–506. [PubMed] [Google Scholar]
  13. Jericho K. W., Darcel C. L., Langford E. V. Respiratory disease in calves produced with aerosols of parainfluenza-3 virus and Pasteurella haemolytica. Can J Comp Med. 1982 Jul;46(3):293–301. [PMC free article] [PubMed] [Google Scholar]
  14. Jericho K. W., Langford E. V. Aerosol vaccination of calves with pasteurella haemolytica against experimental respiratory disease. Can J Comp Med. 1982 Jul;46(3):287–292. [PMC free article] [PubMed] [Google Scholar]
  15. Jericho K. W., Langford E. V. Pneumonia in calves produced with aerosols of bovine herpesvirus 1 and Pasteurella haemolytica. Can J Comp Med. 1978 Jul;42(3):269–277. [PMC free article] [PubMed] [Google Scholar]
  16. Jericho K. W. Update on pasteurellosis in young cattle. Can Vet J. 1979 Nov;20(11):333–335. [PMC free article] [PubMed] [Google Scholar]
  17. KING N. B., GALE C. Studies on myxovirus parainfluenza-3 vaccine for prevention of shipping fever in cattle. J Am Vet Med Assoc. 1963 Apr 15;142:881–883. [PubMed] [Google Scholar]
  18. Kucera C. J., Wong J. C., Eis R. L. Development of a chemically altered Pasteurella multocida vaccinal strain. Am J Vet Res. 1981 Aug;42(8):1389–1394. [PubMed] [Google Scholar]
  19. Lopez A., Maxie M. G., Savan M., Ruhnke H. L., Thomson R. G., Barnum D. A., Geissinger H. D. The pulmonary clearance of Pasteurella haemolytica in calves infected with bovine virus diarrhea or Mycoplasma bovis. Can J Comp Med. 1982 Jul;46(3):302–306. [PMC free article] [PubMed] [Google Scholar]
  20. MOHANTY S. B., LILLIE M. G. EVALUATION OF A BOVINE MYXOVIRUS PARAINFLUENZA-3 (SF-4) VACCINE IN CALVES. Am J Vet Res. 1964 Nov;25:1653–1657. [PubMed] [Google Scholar]
  21. Markham R. J., Wilkie B. N. Interaction between Pasteurella haemolytica and bovine alveolar macrophages: cytotoxic effect on macrophages and impaired phagocytosis. Am J Vet Res. 1980 Jan;41(1):18–22. [PubMed] [Google Scholar]
  22. Martin S. W., Meek A. H., Davis D. G., Johnson J. A., Curtis R. A. Factors associated with morbidity and mortality in feedlot calves: the Bruce County beef project, year two. Can J Comp Med. 1981 Apr;45(2):103–112. [PMC free article] [PubMed] [Google Scholar]
  23. Martin S. W., Meek A. H., Davis D. G., Thomson R. G., Johnson J. A., Lopez A., Stephens L., Curtis R. A., Prescott J. F., Rosendal S. Factors associated with mortality in feedlot cattle: the Bruce County Beef Cattle Project. Can J Comp Med. 1980 Jan;44(1):1–10. [PMC free article] [PubMed] [Google Scholar]
  24. Matsuoka T., Folkerts T. M., Gale C. Evaluation in calves of an inactivated bovine rhinotracheitis and parainfluenza-3 vaccine combined with Pasteurella bacterin. J Am Vet Med Assoc. 1972 Feb 1;160(3):333–337. [PubMed] [Google Scholar]
  25. McKercher D. G., Crenshaw G. L. Comparative efficacy of intranasally and parenterally administered infectious bovine rhinotracheitis vaccines. J Am Vet Med Assoc. 1971 Dec 1;159(11):1362–1369. [PubMed] [Google Scholar]
  26. McKercher D. G., Saito J. K., Franti C. E., Wada E. M., Crenshaw G. L. Response of calves to parainfluenza-3 vaccines administered nasally or parenterally. Am J Vet Res. 1972 Apr;33(4):721–730. [PubMed] [Google Scholar]
  27. Moynihan W. A. Survey of Shipping Fever in Canada: Objectives and Organization of 1954 Survey. Can J Comp Med Vet Sci. 1955 Nov;19(11):327–328. [PMC free article] [PubMed] [Google Scholar]
  28. PALOTAY J. L., YOUNG S., LOVELACE S. A., NEWHALL J. H. BOVINE RESPIRATORY INFECTIONS. II. FIELD TRIAL USING BACTERIAL VACCINE PRODUCTS AS A MEANS OF PROPHYLAXIS. Am J Vet Res. 1963 Nov;24:1137–1142. [PubMed] [Google Scholar]
  29. Peto R., Pike M. C., Armitage P., Breslow N. E., Cox D. R., Howard S. V., Mantel N., McPherson K., Peto J., Smith P. G. Design and analysis of randomized clinical trials requiring prolonged observation of each patient. I. Introduction and design. Br J Cancer. 1976 Dec;34(6):585–612. doi: 10.1038/bjc.1976.220. [DOI] [PMC free article] [PubMed] [Google Scholar]
  30. Peto R., Pike M. C., Armitage P., Breslow N. E., Cox D. R., Howard S. V., Mantel N., McPherson K., Peto J., Smith P. G. Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. analysis and examples. Br J Cancer. 1977 Jan;35(1):1–39. doi: 10.1038/bjc.1977.1. [DOI] [PMC free article] [PubMed] [Google Scholar]
  31. Rehmtulla A. J., Thomson R. G. A review of the lesions in shipping fever of cattle. Can Vet J. 1981 Jan;22(1):1–8. [PMC free article] [PubMed] [Google Scholar]
  32. Rice C. E., Beauregard M., Maybee T. K. Survey of Shipping Fever in Canada: Serological Studies. Can J Comp Med Vet Sci. 1955 Nov;19(11):329–349. [PMC free article] [PubMed] [Google Scholar]
  33. Rothman K. J. Causes. Am J Epidemiol. 1976 Dec;104(6):587–592. doi: 10.1093/oxfordjournals.aje.a112335. [DOI] [PubMed] [Google Scholar]
  34. Savan M., Angulo A. B., Derbyshire J. B. Interferon, antibody responses and protection induced by an intranasal infectious bovine rhinotracheitis vaccine. Can Vet J. 1979 Aug;20(8):207–210. [PMC free article] [PubMed] [Google Scholar]
  35. Schoenbaum S. C., McNeil B. J., Kavet J. The swine-influenza decision. N Engl J Med. 1976 Sep 30;295(14):759–765. doi: 10.1056/NEJM197609302951405. [DOI] [PubMed] [Google Scholar]
  36. Stockdale P. H., Jericho K. W., Yates W. D., Darcel C., Langford E. V. Experimental bovine pneumonic pasteurellosis. II. Genesis and prevention. Can J Comp Med. 1979 Jul;43(3):272–279. [PMC free article] [PubMed] [Google Scholar]
  37. Stockdale P. H., Langford E. V., Darcel C. Experimental bovine pneumonic pasteurellosis. I. Prevention of the disease. Can J Comp Med. 1979 Jul;43(3):262–271. [PMC free article] [PubMed] [Google Scholar]
  38. Todd J. D., Volenec F. J., Paton I. M. Intranasal vaccination against infectious bovine rhinotracheitis: studies on early onset of protection and use of the vaccine in pregnant cows. J Am Vet Med Assoc. 1971 Dec 1;159(11):1370–1374. [PubMed] [Google Scholar]
  39. WOODS G. T., MANSFIELD M. E., CMARIK G., MARQUIS G., SEGRE D. VACCINATION OF BEEF CALVES BEFORE WEANING WITH BOVINE PARAINFLUENZA-3 (SF-4) VACCINE IN AN ADJUVANT. Am J Vet Res. 1964 May;25:704–709. [PubMed] [Google Scholar]
  40. WOODS G. T., MANSFIELD M. E., SEGRE D., HOLPER J. C., BRANDLY C. A., BARTHEL C. The role of viruses in respiratory diseases of cattle. III. Respiratory disease in beef calves vaccinated before weaning with bovine myxovirus para-influenza 3 (SF-4) vaccine. Am J Vet Res. 1962 Jul;23:832–836. [PubMed] [Google Scholar]
  41. WOODS G. T., SEGRE D., BARTHEL C., BRANDLY C. A., HOLPER J. C. The role of viral agents in respiratory disease of cattle. II. A respiratory disease in feeder cattle vaccinated with Pasteurella bacterin and bovine parainfluenza 3 vaccine before shipment. Am J Vet Res. 1962 Sep;23:987–991. [PubMed] [Google Scholar]
  42. WOODS G. T., SINHA S. K., McKEOWN J. A., BRANDLEY C. A. Preshipment vaccination of feeder cattle with bovine para-influenza vaccine. J Am Vet Med Assoc. 1961 Dec 1;139:1208–1211. [PubMed] [Google Scholar]
  43. Woods G. T., Crandell R. A., Mansfield M. E. A comparison of immunologic response to intranasal and intramuscular parainfluenza-3 live virus vaccines in beef calves challenged experimentally in the feedlot. Res Commun Chem Pathol Pharmacol. 1975 May;11(1):117–128. [PubMed] [Google Scholar]
  44. Woods G. T., Mansfield M. E., Cmarik G. F. Effect of certain biologic and antibacterial agents on development of acute respiratory tract disease in weaned beef calves. J Am Vet Med Assoc. 1973 Jun 1;162(11):974–978. [PubMed] [Google Scholar]
  45. Woods G. T., Mansfield M. E., Cmarik G. F., Marquis G. A four-year clinical and serologic study of the use of inactivated parainfluenza-3 virus vaccines and Pasteurella sp. bacterins in beef calves. Vet Med Small Anim Clin. 1974 Apr;69(4):474–passim. [PubMed] [Google Scholar]
  46. Woods G. T., Mansfield M. E., Cmarik G., Krone J. Effects of bovine viral diarrhea and parainfluenza-3 virus vaccines on development of respiratory tract disease in calves. J Am Vet Med Assoc. 1973 Oct 1;163(7):742–744. [PubMed] [Google Scholar]
  47. Woods G. T., Mansfield M. E., Cmarik G., Sibinovic K. Effect of vaccination against bovine myxovirus parainfluenza-3 before weaning and at the time of weaning on the natural history of respiratory disease in beef calves. Am Rev Respir Dis. 1967 Feb;95(2):278–284. doi: 10.1164/arrd.1967.95.2.278. [DOI] [PubMed] [Google Scholar]
  48. Woods G. T., Mansfield M. E., Cmarik G., Zinzilieta M., Marquis G. Vaccination of beef calves before weaning with a live-virus bovine myxovirus parainfluenza-3 vaccine. Am J Vet Res. 1968 Jul;29(7):1349–1353. [PubMed] [Google Scholar]
  49. Woods G. T., Mansfield M. E., Krone J. Active and passive immunity to bovine viral respiratory diseases in beef calves after shipment. Can J Comp Med. 1973 Oct;37(4):336–340. [PMC free article] [PubMed] [Google Scholar]
  50. Yates W. D. A review of infectious bovine rhinotracheitis, shipping fever pneumonia and viral-bacterial synergism in respiratory disease of cattle. Can J Comp Med. 1982 Jul;46(3):225–263. [PMC free article] [PubMed] [Google Scholar]

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