Abstract
Autoantibodies against components of neutrophil cytoplasm develop during adult vasculitic diseases such as Wegener's granulomatosis and microscopic polyarteritis, and they are predominantly of the IgG class. Similar but distinct antibodies have been described in children with Kawasaki disease and both IgM and IgG class antibodies are represented. This adds another clinically distinct childhood form of vasculitis to the adult forms in which autoantibodies to neutrophil cytoplasmic antigens have been detected.
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- Hall J. B., Wadham B. M., Wood C. J., Ashton V., Adam W. R. Vasculitis and glomerulonephritis: a subgroup with an antineutrophil cytoplasmic antibody. Aust N Z J Med. 1984 Jun;14(3):277–278. doi: 10.1111/j.1445-5994.1984.tb03769.x. [DOI] [PubMed] [Google Scholar]
- Kawasaki T. [Acute febrile mucocutaneous syndrome with lymphoid involvement with specific desquamation of the fingers and toes in children]. Arerugi. 1967 Mar;16(3):178–222. [PubMed] [Google Scholar]
- Koeffler H. P. Induction of differentiation of human acute myelogenous leukemia cells: therapeutic implications. Blood. 1983 Oct;62(4):709–721. [PubMed] [Google Scholar]
- Leung D. Y., Chu E. T., Wood N., Grady S., Meade R., Geha R. S. Immunoregulatory T cell abnormalities in mucocutaneous lymph node syndrome. J Immunol. 1983 May;130(5):2002–2004. [PubMed] [Google Scholar]
- Leung D. Y., Collins T., Lapierre L. A., Geha R. S., Pober J. S. Immunoglobulin M antibodies present in the acute phase of Kawasaki syndrome lyse cultured vascular endothelial cells stimulated by gamma interferon. J Clin Invest. 1986 May;77(5):1428–1435. doi: 10.1172/JCI112454. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Leung D. Y., Geha R. S., Newburger J. W., Burns J. C., Fiers W., Lapierre L. A., Pober J. S. Two monokines, interleukin 1 and tumor necrosis factor, render cultured vascular endothelial cells susceptible to lysis by antibodies circulating during Kawasaki syndrome. J Exp Med. 1986 Dec 1;164(6):1958–1972. doi: 10.1084/jem.164.6.1958. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Leung D. Y., Siegel R. L., Grady S., Krensky A., Meade R., Reinherz E. L., Geha R. S. Immunoregulatory abnormalities in mucocutaneous lymph node syndrome. Clin Immunol Immunopathol. 1982 Apr;23(1):100–112. doi: 10.1016/0090-1229(82)90075-7. [DOI] [PubMed] [Google Scholar]
- Lockwood C. M., Bakes D., Jones S., Whitaker K. B., Moss D. W., Savage C. O. Association of alkaline phosphatase with an autoantigen recognised by circulating anti-neutrophil antibodies in systemic vasculitis. Lancet. 1987 Mar 28;1(8535):716–720. doi: 10.1016/s0140-6736(87)90357-6. [DOI] [PubMed] [Google Scholar]
- Lüdemann G., Gross W. L. Autoantibodies against cytoplasmic structures of neutrophil granulocytes in Wegener's granulomatosis. Clin Exp Immunol. 1987 Aug;69(2):350–357. [PMC free article] [PubMed] [Google Scholar]
- Savage C. O., Winearls C. G., Jones S., Marshall P. D., Lockwood C. M. Prospective study of radioimmunoassay for antibodies against neutrophil cytoplasm in diagnosis of systemic vasculitis. Lancet. 1987 Jun 20;1(8547):1389–1393. doi: 10.1016/s0140-6736(87)90591-5. [DOI] [PubMed] [Google Scholar]
- Shulman S. T., Rowley A. H. Does Kawasaki disease have a retroviral aetiology? Lancet. 1986 Sep 6;2(8506):545–546. doi: 10.1016/s0140-6736(86)90115-7. [DOI] [PubMed] [Google Scholar]
- Takiguchi M., Tamura T., Goto M., Kusakawa S., Milgrom F., Kano K. Immunological studies on Kawasaki disease. I. Appearance of Hanganutziu-Deicher antibodies. Clin Exp Immunol. 1984 May;56(2):345–352. [PMC free article] [PubMed] [Google Scholar]
- Walters M. D., Savage C. O., Dillon M. J., Lockwood C. M., Barratt T. M. Antineutrophil cytoplasm antibody in crescentic glomerulonephritis. Arch Dis Child. 1988 Jul;63(7):814–817. doi: 10.1136/adc.63.7.814. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Wathen C. W., Harrison D. J. Circulating anti-neutrophil antibodies in systemic vasculitis. Lancet. 1987 May 2;1(8540):1037–1037. doi: 10.1016/s0140-6736(87)92310-5. [DOI] [PubMed] [Google Scholar]
- Yanagihara R., Todd J. K. Acute febrile mucocutaneous lymph node syndrome. Am J Dis Child. 1980 Jun;134(6):603–614. doi: 10.1001/archpedi.1980.02130180059017. [DOI] [PubMed] [Google Scholar]
- van der Woude F. J., Rasmussen N., Lobatto S., Wiik A., Permin H., van Es L. A., van der Giessen M., van der Hem G. K., The T. H. Autoantibodies against neutrophils and monocytes: tool for diagnosis and marker of disease activity in Wegener's granulomatosis. Lancet. 1985 Feb 23;1(8426):425–429. doi: 10.1016/s0140-6736(85)91147-x. [DOI] [PubMed] [Google Scholar]
- vd Wall Bake A. W., Lobatto S., Jonges L., Daha M. R., van Es L. A. IgA antibodies directed against cytoplasmic antigens of polymorphonuclear leukocytes in patients with Henoch-Schoenlein purpura. Adv Exp Med Biol. 1987;216B:1593–1598. [PubMed] [Google Scholar]