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. 1989 Nov;64(11):1593–1598. doi: 10.1136/adc.64.11.1593

Chronic cough in a hospital population; its relationship to atopy and defects in host defence.

H M Lewis 1, M Haeney 1, J Jeacock 1, H Thomas 1
PMCID: PMC1792647  PMID: 2604419

Abstract

The background and aetiology of chronic cough were investigated by comparing 60 children under 6 years with simple cough, 60 children with asthma, and 60 controls. Both cough and asthma were more common in boys and associated with a history of eczema, chest deformity, and skin reactivity to inhaled allergens, but these findings were more prevalent in asthma than cough. House dust mite sensitivity was found in 34 (57%) children with cough, 45 (75%) with asthma, and six (10%) controls. Tests of immunological function showed some high concentrations of IgM in groups with both cough and asthma, but high IgE concentrations, eosinophilia, and lymphocytosis were significant only in asthma. IgG1 and IgG2 concentrations were raised in some children with cough or asthma, but the only low subclass concentrations were of IgG3 observed in the group with cough. Children with simple cough represented a heterogeneous population but many showed evidence of atopy. Major defects of immunity were not observed.

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Selected References

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  1. Beard L. J., Maxwell G. M., Thong Y. H. Immunocompetence of children with frequent respiratory infections. Arch Dis Child. 1981 Feb;56(2):101–105. doi: 10.1136/adc.56.2.101. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Cloutier M. M., Loughlin G. M. Chronic cough in children: a manifestation of airway hyperreactivity. Pediatrics. 1981 Jan;67(1):6–12. [PubMed] [Google Scholar]
  3. Cloutier M. M. The coughing child. Etiology and treatment of a common symptom. Postgrad Med. 1983 Mar;73(3):169–175. doi: 10.1080/00325481.1983.11697802. [DOI] [PubMed] [Google Scholar]
  4. Eigen H. The clinical evaluation of chronic cough. Pediatr Clin North Am. 1982 Feb;29(1):67–78. doi: 10.1016/s0031-3955(16)34108-6. [DOI] [PubMed] [Google Scholar]
  5. Ellul-Micallef R. Effect of terbutaline sulphate in chronic "allergic" cough. Br Med J (Clin Res Ed) 1983 Oct 1;287(6397):940–943. doi: 10.1136/bmj.287.6397.940. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. French M. A., Harrison G. Systemic antibody deficiency in patients without serum immunoglobulin deficiency or with selective IgA deficiency. Clin Exp Immunol. 1984 Apr;56(1):18–22. [PMC free article] [PubMed] [Google Scholar]
  7. Hannaway P. J., Hopper G. D. Cough variant asthma in children. JAMA. 1982 Jan 8;247(2):206–208. [PubMed] [Google Scholar]
  8. Isaacs D., Altman D. G., Tidmarsh C. E., Valman H. B., Webster A. D. Serum immunoglobulin concentrations in preschool children measured by laser nephelometry: reference ranges for IgG, IgA, IgM. J Clin Pathol. 1983 Oct;36(10):1193–1196. doi: 10.1136/jcp.36.10.1193. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Isaacs D., Clarke J. R., Tyrrell D. A., Valman H. B. Selective infection of lower respiratory tract by respiratory viruses in children with recurrent respiratory tract infections. Br Med J (Clin Res Ed) 1982 Jun 12;284(6331):1746–1748. doi: 10.1136/bmj.284.6331.1746. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Isaacs D., Clarke J. R., Tyrrell D. A., Webster A. D., Valman H. B. Deficient production of leucocyte interferon (interferon-alpha) in vitro and in vivo in children with recurrent respiratory tract infections. Lancet. 1981 Oct 31;2(8253):950–952. doi: 10.1016/s0140-6736(81)91153-3. [DOI] [PubMed] [Google Scholar]
  11. Isaacs D., Webster A. D., Valman H. B. Immunoglobulin levels and function in pre-school children with recurrent respiratory infections. Clin Exp Immunol. 1984 Nov;58(2):335–340. [PMC free article] [PubMed] [Google Scholar]
  12. König P. Hidden asthma in childhood. Am J Dis Child. 1981 Nov;135(11):1053–1055. doi: 10.1001/archpedi.1981.02130350053017. [DOI] [PubMed] [Google Scholar]
  13. Lee D. A., Winslow N. R., Speight A. N., Hey E. N. Prevalence and spectrum of asthma in childhood. Br Med J (Clin Res Ed) 1983 Apr 16;286(6373):1256–1258. doi: 10.1136/bmj.286.6373.1256. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Loftus B. G., Price J. F., Lobo-Yeo A., Vergani D. IgG subclass deficiency in asthma. Arch Dis Child. 1988 Dec;63(12):1434–1437. doi: 10.1136/adc.63.12.1434. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Martin C. J., Platt S. D., Hunt S. M. Housing conditions and ill health. Br Med J (Clin Res Ed) 1987 May 2;294(6580):1125–1127. doi: 10.1136/bmj.294.6580.1125. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Mellis C. M. Evaluation and treatment of chronic cough in children. Pediatr Clin North Am. 1979 Aug;26(3):553–564. doi: 10.1016/s0031-3955(16)33749-x. [DOI] [PubMed] [Google Scholar]
  17. Milner A. D. Psychogenic cough in childhood. Br Med J (Clin Res Ed) 1985 Jun 22;290(6485):1847–1848. doi: 10.1136/bmj.290.6485.1847. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Morgan G., Levinsky R. J. Clinical significance of IgG subclass deficiency. Arch Dis Child. 1988 Jul;63(7):771–773. doi: 10.1136/adc.63.7.771. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Pahor A. L. Night cough in children. Lancet. 1979 Mar 17;1(8116):616–616. [PubMed] [Google Scholar]
  20. Phelan P. D. Postnasal drip and chronic cough. Lancet. 1978 Dec 16;2(8103):1309–1309. doi: 10.1016/s0140-6736(78)92069-x. [DOI] [PubMed] [Google Scholar]
  21. Platts-Mills T. A., Ishizaka K. Activation of the alternate pathway of human complements by rabbit cells. J Immunol. 1974 Jul;113(1):348–358. [PubMed] [Google Scholar]
  22. Richardson V. F., Larcher V. F., Price J. F. A common congenital immunodeficiency predisposing to infection and atopy in infancy. Arch Dis Child. 1983 Oct;58(10):799–802. doi: 10.1136/adc.58.10.799. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Smith C. Night cough in children. Lancet. 1979 Mar 31;1(8118):732–732. doi: 10.1016/s0140-6736(79)91192-9. [DOI] [PubMed] [Google Scholar]
  24. Smith T. F., Bain R. P. IgG subclasses in children with chronic chest symptoms. Monogr Allergy. 1986;20:119–127. [PubMed] [Google Scholar]
  25. Spelman R. Chronic or recurrent cough in children--a presentation of asthma? J R Coll Gen Pract. 1984 Apr;34(261):221–222. [PMC free article] [PubMed] [Google Scholar]
  26. Tanner J. M., Whitehouse R. H., Takaishi M. Standards from birth to maturity for height, weight, height velocity, and weight velocity: British children, 1965. I. Arch Dis Child. 1966 Oct;41(219):454–471. doi: 10.1136/adc.41.219.454. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. Williams H. E. Chronic and recurrent cough. Aust Paediatr J. 1975 Mar;11(1):1–8. doi: 10.1111/j.1440-1754.1975.tb02267.x. [DOI] [PubMed] [Google Scholar]
  28. Yamamura M., Boler J., Valdimarsson H. Phagocytosis measured as inhibition of uridine uptake by Candida albicans. J Immunol Methods. 1977;14(1):19–24. doi: 10.1016/s0022-1759(97)90016-8. [DOI] [PubMed] [Google Scholar]

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