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. 1991 Feb;66(2):189–192. doi: 10.1136/adc.66.2.189

Antiendothelial cell antibodies detected by a cellular based ELISA in Kawasaki disease.

E J Tizard 1, E Baguley 1, G R Hughes 1, M J Dillon 1
PMCID: PMC1792841  PMID: 1900406

Abstract

Kawasaki disease is an acute vasculitic illness of childhood associated with significant morbidity and mortality. A cellular based enzyme linked immunosorbent assay (ELISA) was used to demonstrate the presence of antiendothelial cell antibodies in sera from children with Kawasaki disease. Twenty one of 32 patients with Kawasaki disease had raised IgM antibody titres and four had raised IgG antiendothelial antibody titres. There was a significant difference in the IgM antiendothelial cell antibody titres when comparing the patients with normals and febrile controls. The antibody titre paralleled the disease activity in patients studied serially. There was no relative increase in binding of antiendothelial cell antibodies after cytokine stimulation. These findings may be of importance in further research into the understanding of mechanisms involved in this and other forms of vasculitis in man.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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