Abstract
The increasing use of human growth hormone (hGH) treatment has resulted in the introduction of a number of alternative delivery systems to conventional syringe and needle administration. We examined patients' evaluation of a new delivery system, the Kabipen (Kabi-Vitrum). We also assessed the accuracy of hGH delivery by the Kabipen. Of the 77 survey respondents 13 had used only the Kabipen, 14 the syringe only, and 50 had used both systems. Altogether 46 (92%) of those who had used both systems preferred the Kabipen. Children over 10 years were more likely to self administer hGH with the Kabipen (64%) than syringe (25%). Patient instructions, convenience of use, and comfort of use were rated better for the Kabipen than syringe. With a dose setting of 2 units the Kabipen delivered a mean (SD) of 1.997 (0.073) units with 102.5% recovery from a unit cartridge. In summary the Kabipen is an accurate device clearly preferred by the majority of hGH recipients surveyed.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Albertsson-Wikland K., Westphal O., Westgren U. Daily subcutaneous administration of human growth hormone in growth hormone deficient children. Acta Paediatr Scand. 1986 Jan;75(1):89–97. doi: 10.1111/j.1651-2227.1986.tb10163.x. [DOI] [PubMed] [Google Scholar]
- Frasier S. D., Costin G., Lippe B. M., Aceto T., Jr, Bunger P. F. A dose-response curve for human growth hormone. J Clin Endocrinol Metab. 1981 Dec;53(6):1213–1217. doi: 10.1210/jcem-53-6-1213. [DOI] [PubMed] [Google Scholar]
- Kastrup K. W., Christiansen J. S., Andersen J. K., Orskov H. Increased growth rate following transfer to daily sc administration from three weekly im injections of hGH in growth hormone deficient children. Acta Endocrinol (Copenh) 1983 Oct;104(2):148–152. doi: 10.1530/acta.0.1040148. [DOI] [PubMed] [Google Scholar]
- Koch V. H., Lippe B. M., Nelson P. A., Boechat M. I., Sherman B. M., Fine R. N. Accelerated growth after recombinant human growth hormone treatment of children with chronic renal failure. J Pediatr. 1989 Sep;115(3):365–371. doi: 10.1016/s0022-3476(89)80833-9. [DOI] [PubMed] [Google Scholar]
- Preece M. A., Tanner J. M., Whitehouse R. H., Cameron N. Dose dependence of growth response to human growth hormone in growth hormone deficiency. J Clin Endocrinol Metab. 1976 Mar;42(3):477–483. doi: 10.1210/jcem-42-3-477. [DOI] [PubMed] [Google Scholar]
- Rosenfeld R. G., Hintz R. L., Johanson A. J., Sherman B., Brasel J. A., Burstein S., Chernausek S., Compton P., Frane J., Gotlin R. W. Three-year results of a randomized prospective trial of methionyl human growth hormone and oxandrolone in Turner syndrome. J Pediatr. 1988 Aug;113(2):393–400. doi: 10.1016/s0022-3476(88)80290-7. [DOI] [PubMed] [Google Scholar]
- Saurbrey N., Arnold-Larsen S., Møller-Jensen B., Kühl C. Comparison of continuous subcutaneous insulin infusion with multiple insulin injections using the NovoPen. Diabet Med. 1988 Mar;5(2):150–153. doi: 10.1111/j.1464-5491.1988.tb00962.x. [DOI] [PubMed] [Google Scholar]
- Smith P. J., Hindmarsh P. C., Brook C. G. Contribution of dose and frequency of administration to the therapeutic effect of growth hormone. Arch Dis Child. 1988 May;63(5):491–494. doi: 10.1136/adc.63.5.491. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Takano K., Shizume K., Hibi I. Turner's syndrome: treatment of 203 patients with recombinant human growth hormone for one year. A multicentre study. Acta Endocrinol (Copenh) 1989 May;120(5):559–568. doi: 10.1530/acta.0.1200559. [DOI] [PubMed] [Google Scholar]
- Wit J. M., Fokker M. H., de Muinck Keizer-Schrama S. M., Oostdijk W., Gons M., Otten B. J., Delemarre-Van de Waal H. A., Reeser M., Waelkens J. J. Effects of two years of methionyl growth hormone therapy in two dosage regimens in prepubertal children with short stature, subnormal growth rate, and normal growth hormone response to secretagogues. (Dutch Growth Hormone Working Group). J Pediatr. 1989 Nov;115(5 Pt 1):720–725. doi: 10.1016/s0022-3476(89)80648-1. [DOI] [PubMed] [Google Scholar]