Abstract
Sixteen asthmatic children completed a double blind placebo controlled crossover study of controlled release salbutamol (CRS) to assess its efficacy in controlling night time cough. Children with asthma were enrolled into the study on the basis of a history of persistent cough confirmed by two overnight tape recordings at home. Outcome was measured by two overnight tapes on each medication. Other treatment was unaffected. There was no significant fall in cough counts on CRS. Median scores were 14.5 and 12.0 coughing episodes per night for CRS and placebo respectively. Mean overnight oxygen saturation was identical in both treatment periods but morning peak flow showed a trend towards improvement on CRS. Treatment with CRS does not have a significant effect in control of night cough although it may improve objective measurements of lung function.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Archer L. N., Simpson H. Night cough counts and diary card scores in asthma. Arch Dis Child. 1985 May;60(5):473–474. doi: 10.1136/adc.60.5.473. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Higenbottam T. W., Khan M. A., Williams D. O., Mikhail J. R., Peake M. D., Hughes J. Controlled release salbutamol tablets versus aminophylline in the control of reversible airways obstruction. J Int Med Res. 1989 Sep-Oct;17(5):435–441. doi: 10.1177/030006058901700505. [DOI] [PubMed] [Google Scholar]
- Lipworth B. J., Clark R. A., Dhillon D. P., Charter M. K., Palmer J. B., McDevitt D. G. Single dose and steady-state pharmacokinetics of 4 mg and 8 mg oral salbutamol controlled-release in patients with bronchial asthma. Eur J Clin Pharmacol. 1989;37(1):49–52. doi: 10.1007/BF00609424. [DOI] [PubMed] [Google Scholar]
- Soutar C. A., Carruthers M., Pickering C. A. Nocturnal asthma and urinary adrenaline and noradrenaline excretion. Thorax. 1977 Dec;32(6):677–683. doi: 10.1136/thx.32.6.677. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Thomson A. H., Pratt C., Simpson H. Nocturnal cough in asthma. Arch Dis Child. 1987 Oct;62(10):1001–1004. doi: 10.1136/adc.62.10.1001. [DOI] [PMC free article] [PubMed] [Google Scholar]