Skip to main content
PMC home page
Archives of Disease in Childhood logoLink to Archives of Disease in Childhood
. 1992 Oct;67(10):1250–1254. doi: 10.1136/adc.67.10.1250

Effects of oral and intramuscular vitamin K prophylaxis on vitamin K1, PIVKA-II, and clotting factors in breast fed infants.

E A Cornelissen 1, L A Kollée 1, R A De Abreu 1, J M van Baal 1, K Motohara 1, B Verbruggen 1, L A Monnens 1
PMCID: PMC1793939  PMID: 1444522

Abstract

A randomised clinical trial was conducted to establish the effects of oral and intramuscular administration of vitamin K at birth on plasma concentrations of vitamin K1, proteins induced by vitamin K absence (PIVKA-II), and clotting factors. Two groups of about 165 healthy breast fed infants who received at random 1 mg vitamin K1 orally or intramuscularly after birth were studied at 2 weeks and 1 and 3 months of age. Although vitamin K1 concentrations were statistically significantly higher in the intramuscular group, blood coagulability, activities of factors VII and X and PIVKA-II concentrations did not reveal any difference between the two groups. At 2 weeks of age vitamin K1 concentrations were raised compared with reported unsupplemented concentrations and no PIVKA-II was detectable. At 3 months vitamin K1 concentrations were back at unsupplemented values and PIVKA-II was detectable in 11.5% of infants. Therefore, a repeated oral prophylaxis will be necessary to completely prevent (biochemical) vitamin K deficiency beyond the age of 1 month.

Full text

PDF
1253

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Dreyfus M., Lelong-Tissier M. C., Lombard C., Tchernia G. Vitamin-K deficiency in the newborn. Lancet. 1979 Jun 23;1(8130):1351–1351. doi: 10.1016/s0140-6736(79)91985-8. [DOI] [PubMed] [Google Scholar]
  2. Greer F. R., Marshall S., Cherry J., Suttie J. W. Vitamin K status of lactating mothers, human milk, and breast-feeding infants. Pediatrics. 1991 Oct;88(4):751–756. [PubMed] [Google Scholar]
  3. Jørgensen F. S., Felding P., Vinther S., Andersen G. E. Vitamin K to neonates. Peroral versus intramuscular administration. Acta Paediatr Scand. 1991 Mar;80(3):304–307. doi: 10.1111/j.1651-2227.1991.tb11853.x. [DOI] [PubMed] [Google Scholar]
  4. Lambert W. E., De Leenheer A. P., Baert E. J. Wet-chemical postcolumn reaction and fluorescence detection analysis of the reference interval of endogenous serum vitamin K1(20). Anal Biochem. 1986 Nov 1;158(2):257–261. doi: 10.1016/0003-2697(86)90546-4. [DOI] [PubMed] [Google Scholar]
  5. Lambert W. E., De Leenheer A. P., Lefevere M. F. Determination of vitamin K in serum using HPLC with post-column reaction and fluorescence detection. J Chromatogr Sci. 1986 Feb;24(2):76–79. doi: 10.1093/chromsci/24.2.76. [DOI] [PubMed] [Google Scholar]
  6. McNinch A. W., Tripp J. H. Haemorrhagic disease of the newborn in the British Isles: two year prospective study. BMJ. 1991 Nov 2;303(6810):1105–1109. doi: 10.1136/bmj.303.6810.1105. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. McNinch A. W., Upton C., Samuels M., Shearer M. J., McCarthy P., Tripp J. H., L'E Orme R. Plasma concentrations after oral or intramuscular vitamin K1 in neonates. Arch Dis Child. 1985 Sep;60(9):814–818. doi: 10.1136/adc.60.9.814. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Motohara K., Endo F., Matsuda I. Effect of vitamin K administration on acarboxy prothrombin (PIVKA-II) levels in newborns. Lancet. 1985 Aug 3;2(8449):242–244. doi: 10.1016/s0140-6736(85)90291-0. [DOI] [PubMed] [Google Scholar]
  9. Motohara K., Endo F., Matsuda I. Vitamin K deficiency in breast-fed infants at one month of age. J Pediatr Gastroenterol Nutr. 1986 Nov-Dec;5(6):931–933. doi: 10.1097/00005176-198611000-00019. [DOI] [PubMed] [Google Scholar]
  10. Motohara K., Kuroki Y., Kan H., Endo F., Matsuda I. Detection of vitamin K deficiency by use of an enzyme-linked immunosorbent assay for circulating abnormal prothrombin. Pediatr Res. 1985 Apr;19(4):354–357. doi: 10.1203/00006450-198519040-00008. [DOI] [PubMed] [Google Scholar]
  11. O'Connor M. E., Addiego J. E., Jr Use of oral vitamin K1 to prevent hemorrhagic disease of the newborn infant. J Pediatr. 1986 Apr;108(4):616–619. doi: 10.1016/s0022-3476(86)80851-4. [DOI] [PubMed] [Google Scholar]
  12. Pietersma-de Bruyn A. L., van Haard P. M., Beunis M. H., Hamulyák K., Kuijpers J. C. Vitamin K1 levels and coagulation factors in healthy term newborns till 4 weeks after birth. Haemostasis. 1990;20(1):8–14. doi: 10.1159/000216099. [DOI] [PubMed] [Google Scholar]
  13. Shapiro A. D., Jacobson L. J., Armon M. E., Manco-Johnson M. J., Hulac P., Lane P. A., Hathaway W. E. Vitamin K deficiency in the newborn infant: prevalence and perinatal risk factors. J Pediatr. 1986 Oct;109(4):675–680. doi: 10.1016/s0022-3476(86)80241-4. [DOI] [PubMed] [Google Scholar]
  14. Shearer M. J., Mallinson C. N., Webster G. R., Barkhan P. Clearance from plasma and excretion in urine, faeces and bile of an intravenous dose of tritiated vitamin K 1 in man. Br J Haematol. 1972 May;22(5):579–588. doi: 10.1111/j.1365-2141.1972.tb05704.x. [DOI] [PubMed] [Google Scholar]
  15. Sutor A. H., Göbel U., Kries R. V., Künzer W., Landbeck G. Vitamin K prophylaxis in the newborn. Blut. 1990 May;60(5):275–277. doi: 10.1007/BF01736227. [DOI] [PubMed] [Google Scholar]
  16. Tönz O., Schubiger G. Neonatale Vitamin-K-Prophylaxe und Vitamin-K-Mangelblutungen in der Schweiz 1986-1988. Schweiz Med Wochenschr. 1988 Nov 26;118(47):1747–1752. [PubMed] [Google Scholar]
  17. Wallin R. Vitamin K-dependent carboxylation in the developing rat: evidence for a similar mechanism of action of warfarin in fetal and adult livers. Pediatr Res. 1989 Oct;26(4):370–376. doi: 10.1203/00006450-198910000-00017. [DOI] [PubMed] [Google Scholar]
  18. Widdershoven J., Kollée L., van Munster P., Bosman A. M., Monnens L. Biochemical vitamin K deficiency in early infancy: diagnostic limitation of conventional coagulation tests. Helv Paediatr Acta. 1986 Aug;41(3):195–201. [PubMed] [Google Scholar]
  19. Widdershoven J., Lambert W., Motohara K., Monnens L., de Leenheer A., Matsuda I., Endo F. Plasma concentrations of vitamin K1 and PIVKA-II in bottle-fed and breast-fed infants with and without vitamin K prophylaxis at birth. Eur J Pediatr. 1988 Nov;148(2):139–142. doi: 10.1007/BF00445922. [DOI] [PubMed] [Google Scholar]
  20. von Kries R., Kreppel S., Becker A., Tangermann R., Göbel U. Acarboxyprothrombin concentration [corrected] after oral prophylactic vitamin K. Arch Dis Child. 1987 Sep;62(9):938–940. doi: 10.1136/adc.62.9.938. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. von Kries R. Neonatal vitamin K. BMJ. 1991 Nov 2;303(6810):1083–1084. doi: 10.1136/bmj.303.6810.1083. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. von Kries R., Shearer M. J., Göbel U. Vitamin K in infancy. Eur J Pediatr. 1988 Feb;147(2):106–112. doi: 10.1007/BF00442204. [DOI] [PubMed] [Google Scholar]

Articles from Archives of Disease in Childhood are provided here courtesy of BMJ Publishing Group

RESOURCES