Abstract
In 11 patients receiving transplants of allogeneic bone marrow, the graft was successful in six. Nine patients developed infections, and six died—five of septicaemia and one of Pneumocystis carinii pneumonia. Fifty individual infections occurred. Predisposing factors included severe underlying diseases, long-term exposure to resistant hospital organisms, heavy immunosuppressive therapy, and graft-versus-host disease. Gram-negative bacilli and Candida albicans were the most common causative organisms. In every instance of septicaemia identical organisms were isolated from blood cultures and simultaneously obtained stool cultures. Infection with exogenous organisms often occurred in patients occupying conventional isolation rooms. Isolation of one patient for 45 days in a laminar air flow room prevented infection with exogenous organisms.
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- BLAESE R. M., MARTINEZ C., GOOD R. A. IMMUNOLOGIC INCOMPETENCE OF IMMUNOLOGICALLY RUNTED ANIMALS. J Exp Med. 1964 Feb 1;119:211–224. doi: 10.1084/jem.119.2.211. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Bauer A. W., Kirby W. M., Sherris J. C., Turck M. Antibiotic susceptibility testing by a standardized single disk method. Am J Clin Pathol. 1966 Apr;45(4):493–496. [PubMed] [Google Scholar]
- Epstein R. B., Storb R., Clift R. A., Thomas E. D. Autologous bone marrow grafts in dogs treated with lethal doses of cyclophosphamide. Cancer Res. 1969 May;29(5):1072–1075. [PubMed] [Google Scholar]
- Fulginiti V. A., Scribner R., Groth C. G., Putnam C. W., Brettschneider L., Gilbert S., Porter K. A., Starzl T. E. Infections in recipients of liver homografts. N Engl J Med. 1968 Sep 19;279(12):619–626. doi: 10.1056/NEJM196809192791202. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Keast D. A simple index for the measurement of the runting syndrome and its use in the study of the influence of the gut flora in its production. Immunology. 1968 Aug;15(2):237–245. [PMC free article] [PubMed] [Google Scholar]
- Kelly W. D., Lillehei R. C., Aust J. B., Varco R. L., Leonard A. S., Griffin W. O., Markland C., Herdman R. C., Vernier R. L., Michael A. F. Kindey transplantation: experiences at the University of Minnesota Hospitals. Surgery. 1967 Oct;62(4):704–720. [PubMed] [Google Scholar]
- Ledney G. D. Antilymphocyte serum in the therapy and prevention of acute secondary disease in mice. Transplantation. 1969 Aug;8(2):127–140. doi: 10.1097/00007890-196908000-00005. [DOI] [PubMed] [Google Scholar]
- Mathe G., Schwarzenberg L., de Vries M. J., Amiel J. L., Cattan A., Schneider M., Binet J. L., Tubiana M., Lalanne C., Schwarzmann V. Les divers aspects du syndrome secondaire compliquant les tranfusions allogéniques de moelle osseuse ou de leucocytes chez des sujets atteints d'hémopathies malignes. Eur J Cancer. 1965 Oct;1(2):75–113. doi: 10.1016/0014-2964(65)90001-0. [DOI] [PubMed] [Google Scholar]
- Meuwissen H. J., Gatti R. A., Terasaki P. I., Hong R., Good R. A. Treatment of lymphopenic hypogammaglobulinemia and bone-marrow aplasia by transplantation of allogeneic marrow. Crucial role of histocompatiility matching. N Engl J Med. 1969 Sep 25;281(13):691–697. doi: 10.1056/NEJM196909252811302. [DOI] [PubMed] [Google Scholar]
- RIFKIND D., MARCHIORO T. L., WADDELL W. R., STARZL T. E. INFECTIOUS DISEASES ASSOCIATED WITH RENAL HOMOTRANSPLANTATION. JAMA. 1964 Aug 10;189:397–407. doi: 10.1001/jama.1964.03070060007001. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Rifkind D., Faris T. D., Hill R. B., Jr Pneumocystis carinii pneumonia. Studies on the diagnosis and treatment. Ann Intern Med. 1966 Nov;65(5):943–956. doi: 10.7326/0003-4819-65-5-943. [DOI] [PubMed] [Google Scholar]
- de VRIES M., CROUCH B. G., van PUTTEN L., van BEKKUM D. Pathologic changes in irradiated monkeys treated with bone marrow. J Natl Cancer Inst. 1961 Jul;27:67–97. [PubMed] [Google Scholar]