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. 1971 Feb 20;1(5746):423–426. doi: 10.1136/bmj.1.5746.423

Effect of Actinomycin D on Paget's Disease of Bone

James J Fennelly, Joseph F Groarke
PMCID: PMC1795089  PMID: 5101343

Abstract

Four patients with active Paget's disease were treated with the RNA inhibitor actinomycin D. Three were clinically improved after treatment; the fourth had multiple collapsed vertebrae and showed no symptomatic improvement. Striking changes took place in urinary calcium and hydroxyproline, in serum alkaline phosphatase, and to a less extent in serum calcium and phosphate. These studies are continuing and are being compared with the effects of mithramycin.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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