Skip to main content
PMC home page
British Medical Journal logoLink to British Medical Journal
. 1971 Apr 3;2(5752):25–26. doi: 10.1136/bmj.2.5752.25

Controlled Trial of Metoclopramide in the Treatment of Flatulent Dyspepsia

A G Johnson
PMCID: PMC1795898  PMID: 4927813

Abstract

A double-blind cross-over trial of metoclopramide (Maxolon) against placebo was undertaken in 42 patients with flatulent dyspepsia. A highly significant difference was found in favour of the active drug (P<0·01). The time at which the drug is given in relation to the meal and onset of symptoms is probably important. It is concluded that metoclopramide is effective in the short-term treatment of these symptoms but should be started only after thorough investigations have excluded more serious disease.

Full text

PDF
25

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BODVALL B. LATE RESULTS FOLLOWING CHOLECYSTECTOMY IN 1930 CASES AND SPECIAL STUDIES ON POSTOPERATIVE BILIARY DISTRESS. Acta Chir Scand Suppl. 1964;325:SUPPL 329–329:1+. [PubMed] [Google Scholar]
  2. Boisson J., Albot G. Sur l'intérêt thérapeutique du métoclopramide. A propos de 2 300 observations. Revue critique et indications de son emploi. Cah Coll Med Hop Paris. 1966 Jan;7(1):45–63. [PubMed] [Google Scholar]
  3. Capper W. M., Butler T. J., Kilby J. O., Gibson M. J. Gallstones, gastric secretion, and flatulent dyspepsia. Lancet. 1967 Feb 25;1(7487):413–415. doi: 10.1016/s0140-6736(67)91176-2. [DOI] [PubMed] [Google Scholar]
  4. Connell A. M., George J. D. Effect of metoclopramide on gastric function in man. Gut. 1969 Aug;10(8):678–680. doi: 10.1136/gut.10.8.678. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Jacoby H. I., Brodie D. A. Gastrointestinal actions of metoclopramide. An experimental study. Gastroenterology. 1967 Apr;52(4):676–684. [PubMed] [Google Scholar]
  6. Johnson A. G. The effect of metoclopramide on gastroduodenal and gallbladder contractions. Gut. 1971 Feb;12(2):158–163. doi: 10.1136/gut.12.2.158. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Kreel L. The use of oral Metoclopramide in the barium meal and follow-through examination. Br J Radiol. 1970 Jan;43(505):31–35. doi: 10.1259/0007-1285-43-505-31. [DOI] [PubMed] [Google Scholar]
  8. Marshall N. W. A double-blind trial of metoclopramide and prochlorperazine in general practice. Br J Clin Pract. 1970 Jan;24(1):25–27. [PubMed] [Google Scholar]
  9. PRICE W. H. Gall-bladder dyspepsia. Br Med J. 1963 Jul 20;2(5350):138–141. doi: 10.1136/bmj.2.5350.138. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Rhind J. A., Watson L. Gall stone dyspepsia. Br Med J. 1968 Jan 6;1(5583):32–32. doi: 10.1136/bmj.1.5583.32. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Trafford J. A., Fisher A. M., Marshall S., Douthwaite A. H. Metoclopramide ('Maxolon')--a new anti-emetic. Br J Clin Pract. 1967 Sep 9;21(9):457–460. [PubMed] [Google Scholar]

Articles from British Medical Journal are provided here courtesy of BMJ Publishing Group

RESOURCES