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. 1971 Aug 7;3(5770):347–350. doi: 10.1136/bmj.3.5770.347

Effects of Poisoning on Serum Enzyme Activities, Coagulation, and Fibrinolysis

N Wright, A R Clarkson, S S Brown, V Fuster
PMCID: PMC1798583  PMID: 5558188

Abstract

Prolonged coma due to acute overdosage with hypnotic drugs is shown to be associated with a pronounced increase in the activity of serum creatine kinase and in the concentration of fibrin degradation products and with less pronounced abnormalities of other serum enzymes and of other indices of coagulation and fibrinolysis. Evidence is presented that skeletal muscle damage occurs and that this is related to the coagulation abnormality. These findings probably explain some of the non-specific features such as fever which commonly occur in recovery from severe poisoning.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BEVERIDGE G. W., LAWSON A. A. OCCURRENCE OF BULLOUS LESIONS IN ACUTE BARBITURATE INTOXICATION. Br Med J. 1965 Mar 27;1(5438):835–837. doi: 10.1136/bmj.1.5438.824. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Bonnar J., McNicol G. P., Douglas A. S. Coagulation and fibrinolytic mechanisms during and after normal childbirth. Br Med J. 1970 Apr 25;2(5703):200–203. doi: 10.1136/bmj.2.5703.200. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Cash J. D., Leask E. Mutichannel system for the automatic recording of clot lysis. J Clin Pathol. 1967 Mar;20(2):209–211. doi: 10.1136/jcp.20.2.209. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Chakrabarti R., Hocking E. D., Fearnley G. R. Reaction pattern to three stresses--electroplexy, surgery, and myocardial infarction--of fibrinolysis and plasma fibrinogen. J Clin Pathol. 1969 Nov;22(6):659–662. doi: 10.1136/jcp.22.6.659. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Clark J. G., Sumerling M. D. Muscle necrosis and calcification in acute renal failure due to barbiturate intoxication. Br Med J. 1966 Jul 23;2(5507):214–215. doi: 10.1136/bmj.2.5507.214. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Clarkson A. R., MacDonald M. K., Fuster V., Cash J. D., Robson J. S. Glomerular coagulation in acute ischaemic renal failure. Q J Med. 1970 Oct;39(156):585–599. [PubMed] [Google Scholar]
  7. DUGUID H., SIMPSON R. G., STOWERS J. M. Accidental hypothermia. Lancet. 1961 Dec 2;2(7214):1213–1219. doi: 10.1016/s0140-6736(61)92588-0. [DOI] [PubMed] [Google Scholar]
  8. ELLIS B. C., STRANSKY A. A quick and accurate method for the determination of fibronogen in plasma. J Lab Clin Med. 1961 Sep;58:477–488. [PubMed] [Google Scholar]
  9. Henderson L. W., Metz M., Wilkinson J. H. Serum enzyme elevation in glutethimide intoxication. Br Med J. 1970 Sep 26;3(5725):751–751. doi: 10.1136/bmj.3.5725.751. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. INNES D., SEVITT S. COAGULATION AND FIBRINOLYSIS IN INJURED PATIENTS. J Clin Pathol. 1964 Jan;17:1–13. doi: 10.1136/jcp.17.1.1. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Leavell U. W. Sweat gland necrosis in barbiturate poisoning. Arch Dermatol. 1969 Aug;100(2):218–221. [PubMed] [Google Scholar]
  12. Lipiński B., Worowski K. Detection of soluble fibrin monomer complexes in blood by means of protamine sulphate test. Thromb Diath Haemorrh. 1968 Nov 15;20(1):44–49. [PubMed] [Google Scholar]
  13. Maclean D., Griffiths P. D., Emslie-Smith D. Serum-enzymes in relation to electrocardiographic changes in accidental hypothermia. Lancet. 1968 Dec 14;2(7581):1266–1270. doi: 10.1016/s0140-6736(68)91761-3. [DOI] [PubMed] [Google Scholar]
  14. Mandy S., Ackerman A. B. Characteristic traumatic skin lesions in drug-induced coma. JAMA. 1970 Jul 13;213(2):253–256. [PubMed] [Google Scholar]
  15. Meltzer H. Possible mechanism of increased intravascular clotting in malignant hyperpyrexia. Lancet. 1971 May 1;1(7705):918–919. doi: 10.1016/s0140-6736(71)92488-3. [DOI] [PubMed] [Google Scholar]
  16. Merskey C., Kleiner G. J., Johnson A. J. Quantitative estimation of split products of fibrinogen in human serum, relation to diagnosis and treatment. Blood. 1966 Jul;28(1):1–18. [PubMed] [Google Scholar]
  17. POPLAWSKI A., NIEWIAROWSKI S. METHOD FOR DETERMINING ANTIHEPARIN ACTIVITY OF PLATELETS AND ERYTHROCYTES. Thromb Diath Haemorrh. 1965 Mar 15;13:149–154. [PubMed] [Google Scholar]
  18. REED C. E., DRIGGS M. F., FOOTE C. C. Acute barbiturate intoxication: a study of 300 cases based on a physiologic system of classification of the severity of the intoxication. Ann Intern Med. 1952 Aug;37(2):290–303. doi: 10.7326/0003-4819-37-2-290. [DOI] [PubMed] [Google Scholar]
  19. Smith A. F., Brown S. S., Taylor R. Assessment of an automatic enzyme reaction rate monitor. Clin Chim Acta. 1970 Oct;30(1):105–113. doi: 10.1016/0009-8981(70)90198-1. [DOI] [PubMed] [Google Scholar]
  20. Smith A. F., Macfie W. G., Oliver M. F. Clofibrate, serum enzymes, and muscle pain. Br Med J. 1970 Apr 11;2(5701):86–88. doi: 10.1136/bmj.2.5701.86. [DOI] [PMC free article] [PubMed] [Google Scholar]

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