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. 1971 Nov 20;4(5785):454–458. doi: 10.1136/bmj.4.5785.454

Present Status of Subclinical Intestinal Malabsorption in the Tropics

J M Falaiye
PMCID: PMC1799675  PMID: 5125280

Abstract

A review of the literature on subclinical intestinal disease shows its probable relevance in certain nutritional deficiencies in the indigenous residents of tropical climates. A significant incidence of intestinal disease has been defined among asymptomatic fit-looking adult Nigerians. The results of subsequent investigation into the pathogenesis of this disorder strongly point to hypoalbuminaemia as the important factor capable of producing a biochemically and histologically defined malabsorptive state leading to subnormal nutritional status among members of this community.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. AMINI F. Giardiasis and steatorrhoea. J Trop Med Hyg. 1963 Jul;66:190–192. [PubMed] [Google Scholar]
  2. BANWELL J. G., HUTT M. S., TUNNICLIFFE R. OBSERVATIONS ON JEJUNAL BIOPSY IN UGANDAN AFRICANS. East Afr Med J. 1964 Feb;41:46–54. [PubMed] [Google Scholar]
  3. BUTTERWORTH C. E., Jr, PEREZ-SANTIAGO E. Jejunal biopsies in sprue. Ann Intern Med. 1958 Jan;48(1):8–29. doi: 10.7326/0003-4819-48-1-8. [DOI] [PubMed] [Google Scholar]
  4. Burman D. The jejunal mucosa in kwashiorkor. Arch Dis Child. 1965 Oct;40(213):526–531. doi: 10.1136/adc.40.213.526. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. CHACKO C. J., JOB C. K., JOHNSON S., BAKER S. J. Histopathological changes in the upper jejunum in tropical malabsorption syndrome studied by transoral biopsy. Indian J Pathol Bacteriol. 1961 Oct;4:203–213. [PubMed] [Google Scholar]
  6. Colwell E. J., Welsh J. D., Legters L. J., Proctor R. F. Jejunal morphological characteristics in South Vietnamese residents. JAMA. 1968 Dec 2;206(10):2273–2276. [PubMed] [Google Scholar]
  7. DRUSKIN M. S., WALLEN M. H., BONAGURA L. Anticonvulsant-associated megaloblastic anemia. Response to 25 microgm. of folic acid administered by mouth daily. N Engl J Med. 1962 Sep 6;267:483–485. doi: 10.1056/NEJM196209062671004. [DOI] [PubMed] [Google Scholar]
  8. Falaiye J. M. Tropical sprue in Nigeria. J Trop Med Hyg. 1970 May;73(5):119–125. [PubMed] [Google Scholar]
  9. Ingelfinger F. J. Malabsorption: the clinical background. Fed Proc. 1967 Sep;26(5):1388–1390. [PubMed] [Google Scholar]
  10. Jeejeebhoy K. N., Desai H. G., Noronha J. M., Antia F. P., Parekh D. V. Idiopathic tropical diarrhea with or without steatorrhea (tropical malabsorption syndrome). Gastroenterology. 1966 Sep;51(3):333–344. [PubMed] [Google Scholar]
  11. KLIPSTEIN F. A. TROPICAL SPRUE IN NEW YORK CITY. Gastroenterology. 1964 Nov;47:457–470. [PubMed] [Google Scholar]
  12. Klipstein F. A., Falaiye J. M. Tropical sprue in expatriates from the tropics living in the continental United States. Medicine (Baltimore) 1969 Nov;48(6):475–491. doi: 10.1097/00005792-196948060-00003. [DOI] [PubMed] [Google Scholar]
  13. Klipstein F. A., Samloff I. M., Schenk E. A. Tropical sprue in Haiti. Ann Intern Med. 1966 Mar;64(3):575–594. doi: 10.7326/0003-4819-64-3-575. [DOI] [PubMed] [Google Scholar]
  14. LEBLOND C. P., MESSIER B. Renewal of chief cells and goblet cells in the small intestine as shown by radioautography after injection of thymidine-H3 into mice. Anat Rec. 1958 Nov;132(3):247–259. doi: 10.1002/ar.1091320303. [DOI] [PubMed] [Google Scholar]
  15. LEBLOND C. P., WALKER B. E. Renewal of cell populations. Physiol Rev. 1956 Apr;36(2):255–276. doi: 10.1152/physrev.1956.36.2.255. [DOI] [PubMed] [Google Scholar]
  16. LINDENBAUM J. MALABSORPTION DURING AND AFTER RECOVERY FROM ACUTE INTESTINAL INFECTION. Br Med J. 1965 Aug 7;2(5457):326–329. doi: 10.1136/bmj.2.5457.326. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Lindenbaum J., Alam A. K., Kent T. H. Subclinical small-intestinal disease in East Pakistan. Br Med J. 1966 Dec 31;2(5530):1616–1619. doi: 10.1136/bmj.2.5530.1616. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Lindenbaum J., Kent T. H., Sprinz H. Malabsorption and jejunitis in American Peace Corps volunteers in Pakistan. Ann Intern Med. 1966 Dec;65(6):1201–1209. doi: 10.7326/0003-4819-65-6-1201. [DOI] [PubMed] [Google Scholar]
  19. Milner P. F., Irvine R. A., Barton C. J., Bras G., Richards R. Intestinal malabsorption in Strongyloides stercoralis infestation. Gut. 1965 Dec;6(6):574–581. doi: 10.1136/gut.6.6.574. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Russell P. K., Aziz M. A., Ahmad N., Kent T. H., Gangarosa E. J. Enteritis and gastritis in young asymptomatic Pakistani men. Am J Dig Dis. 1966 Apr;11(4):296–306. doi: 10.1007/BF02233978. [DOI] [PubMed] [Google Scholar]
  21. SHEEHY T. W., RUBINI M. E., PEREZ-SANTIAGO E., SANTINI R., Jr, HADDOCK J. The effect of "minute" and "titrated" amounts of folic acid on the megaloblastic anemia of tropical sprue. Blood. 1961 Dec;18:623–636. [PubMed] [Google Scholar]
  22. SPRINZ H., SRIBHIBHADH R., GANGAROSA E. J., BENYAJATI C., KUNDEL D., HALSTEAD S. Biopsy of small bowel of Thai people. With special reference to recovery from Asiatic cholera and to an intestinal malabsorption syndrome. Am J Clin Pathol. 1962 Jul;38:43–51. doi: 10.1093/ajcp/38.1.43. [DOI] [PubMed] [Google Scholar]
  23. Sheehy T. W., Legters L. J., Wallace D. K. Tropical jejunitis in Americans serving in Vietnam. Am J Clin Nutr. 1968 Sep;21(9):1013–1022. doi: 10.1093/ajcn/21.9.1013. [DOI] [PubMed] [Google Scholar]
  24. Stanfield J. P., Hutt M. S., Tunnicliffe R. Intestinal biopsy in kwashiorkor. Lancet. 1965 Sep 11;2(7411):519–523. doi: 10.1016/s0140-6736(65)91474-1. [DOI] [PubMed] [Google Scholar]
  25. Tandon B. N., Das B. C., Saraya A. K., Deo M. G. Functional and structural studies of small bowel in ankylostomiasis. Br Med J. 1966 Mar 19;1(5489):714–716. doi: 10.1136/bmj.1.5489.714. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. Tandon B. N., Saraya A. K., Ramachandran K., Sama S. K. Relationship of anaemia and hypoproteinaemia to the functional and structural changes in the small bowel in hookworm disease. Gut. 1969 May;10(5):360–365. doi: 10.1136/gut.10.5.360. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. WATSON W. C., PATON E., MURRAY D. SMALL-BOWEL DISEASE IN ROSACEA. Lancet. 1965 Jul 10;1(7402):47–50. doi: 10.1016/s0140-6736(65)90128-5. [DOI] [PubMed] [Google Scholar]
  28. ZALUSKY R., HERBERT V. Megaloblastic anemia in scurvy with response to 50 microgm. of folic acid daily. N Engl J Med. 1961 Nov 23;265:1033–1038. doi: 10.1056/NEJM196111232652103. [DOI] [PubMed] [Google Scholar]

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