Skip to main content
PMC home page
Canadian Medical Association Journal logoLink to Canadian Medical Association Journal
. 1980 Jun 21;122(12):1390–1393.

Platelet regeneration time and late occlusion of aortocoronary saphenous vein bypass grafts.

J G Latour, J R Trudel, L Campeau, P Côté, M G Bourassa, F Corbara, C B Solymoss
PMCID: PMC1801921  PMID: 6973384

Abstract

The half-time for platelet regeneration was estimated in 16 patients with aortocoronary vein grafts by the use of a non-radioisotopic technique based on the permanent inhibition by acetylsalicylic acid of lipid peroxidation by platelets. Ten patients had patent grafts after 6 years; in the other six at least one graft had become occluded between 2 and 6 years after the operation as shown by serial angiography. The mean half-time (+/- the standard error) for platelet regeneration was reduced to 2.5 +/- 0.2 days (P less than 0.002) in the group with occluded grafts as compared with 3.3 +/- 11 healthy volunteers. These results suggest a relation between late graft occlusion and platelet turnover and support the idea that patients with aortocoronary vein grafts could benefit from platelet suppressive therapy. Finally, the method employed appears to be a useful and simple way of evaluating platelet function in vivo.

Full text

PDF
1393

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Allard C., Goulet C., Grondin C. M., Lesperance J., Bourassa M. G. Patency of aortocoronary vein grafts and serum triglycerides. Three year follow-up study. Am J Cardiol. 1974 May 6;33(5):679–680. doi: 10.1016/0002-9149(74)90262-8. [DOI] [PubMed] [Google Scholar]
  2. Barboriak J. J., Pintar K., Korns M. E. Atherosclerosis in aortocoronary vein grafts. Lancet. 1974 Sep 14;2(7881):621–624. doi: 10.1016/s0140-6736(74)91945-x. [DOI] [PubMed] [Google Scholar]
  3. Barboriak J. J., Pintar K., Van Horn D. L., Batayias G. E., Korns M. E. Pathologic findings in the aortocoronary vein grafts. A scanning electron microscope study. Atherosclerosis. 1978 Jan;29(1):69–80. doi: 10.1016/0021-9150(78)90095-3. [DOI] [PubMed] [Google Scholar]
  4. Bulkley B. H., Hutchins G. M. Accelerated "atherosclerosis". A morphologic study of 97 saphenous vein coronary artery bypass grafts. Circulation. 1977 Jan;55(1):163–169. doi: 10.1161/01.cir.55.1.163. [DOI] [PubMed] [Google Scholar]
  5. Carvalho A. C., Colman R. W., Lees R. S. Platelet function in hyperlipoproteinemia. N Engl J Med. 1974 Feb 21;290(8):434–438. doi: 10.1056/NEJM197402212900805. [DOI] [PubMed] [Google Scholar]
  6. Cortellaro M., Boschetti C., Fassio G., Basagni M., Polli E. E. A controlled study of the effect of sulfinpyrazone on platelet survival and on platelet-bound 14C-serotonin release in patients with previous myocardial infarction. Acta Haematol. 1979;61(2):68–74. doi: 10.1159/000207634. [DOI] [PubMed] [Google Scholar]
  7. Grondin C. M., Campeau L., Lespérance J., Solymoss B. C., Vouhé P., Castonguay Y. R., Meere C., Bourassa M. G. Atherosclerotic changes in coronary vein grafts six years after operation. Angiographic aspect in 110 patients. J Thorac Cardiovasc Surg. 1979 Jan;77(1):24–31. [PubMed] [Google Scholar]
  8. Grondin C. M., Lespérance J., Bourassa M. G., Pasternac A., Campneau L., Grondin P. Serial angiograpic evaluation in 60 consecutive patients with aorto-coronary artery vein grafts 2 weeks, 1 year, and 3 years after operation. J Thorac Cardiovasc Surg. 1974 Jan;67(1):1–6. [PubMed] [Google Scholar]
  9. Kern W. H., Dermer G. B., Lindesmith G. G. The intimal proliferation in aortic-coronary saphenous vein grafts. Light and electron microscopic studies. Am Heart J. 1972 Dec;84(6):771–777. doi: 10.1016/0002-8703(72)90070-1. [DOI] [PubMed] [Google Scholar]
  10. Latour J. G., Leger C. Prevention by glucocorticoids of disseminated intravascular coagulation induced by endotoxin: mechanisms. J Lab Clin Med. 1975 Jun;85(6):934–949. [PubMed] [Google Scholar]
  11. Lespérance J., Bourassa M. G., Biron P., Campeau L., Saltiel J. Aorta to coronary artery saphenous vein grafts. Preoperative angiographic criteria for successful surgery. Am J Cardiol. 1972 Oct;30(5):459–465. doi: 10.1016/0002-9149(72)90034-3. [DOI] [PubMed] [Google Scholar]
  12. MUSTARD J. F., MURPHY E. A. Effect of different dietary fats on blood coagulation, platelet economy, and blood lipids. Br Med J. 1962 Jun 16;1(5293):1651–1655. doi: 10.1136/bmj.1.5293.1651. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Marchandise B., Latour J. G., Bourassa M. G., Beaulac P., Yu S. K. Platelet hyperreactivity to thrombin in patients with myocardial infarction and normal or slightly abnormal coronary arteries. Clin Invest Med. 1979;2(1):41–49. [PubMed] [Google Scholar]
  14. Mustard J. F. Platelet survival. Thromb Haemost. 1978 Aug 31;40(1):154–162. [PubMed] [Google Scholar]
  15. Okuma M., Steiner M., Baldini M. Studies on lipid peroxides in platelets. I. Method of assay and effect of storage. J Lab Clin Med. 1970 Feb;75(2):283–296. [PubMed] [Google Scholar]
  16. Placer Z. A., Cushman L. L., Johnson B. C. Estimation of product of lipid peroxidation (malonyl dialdehyde) in biochemical systems. Anal Biochem. 1966 Aug;16(2):359–364. doi: 10.1016/0003-2697(66)90167-9. [DOI] [PubMed] [Google Scholar]
  17. Ritchie J. L., Harker L. A. Platelet and fibrinogen survival in coronary atherosclerosis. Response to medical and surgical therapy. Am J Cardiol. 1977 Apr;39(4):595–598. doi: 10.1016/s0002-9149(77)80171-9. [DOI] [PubMed] [Google Scholar]
  18. Roberts W. C., Ferrans V. J. The role of thrombosis in the etiology of atherosclerosis (a positive one) and in precipitating fatal ischemic heart disease (a negative one). Semin Thromb Hemost. 1976 Jan;2(3):123–135. doi: 10.1055/s-0028-1086120. [DOI] [PubMed] [Google Scholar]
  19. Steele P. P., Weily H. S., Davies H., Genton E. Platelet function studies in coronary artery disease. Circulation. 1973 Dec;48(6):1194–1200. doi: 10.1161/01.cir.48.6.1194. [DOI] [PubMed] [Google Scholar]
  20. Steele P., Battock D., Genton E. Effects of clofibrate and sulfinpyrazone on platelet survival time in coronary artery disease. Circulation. 1975 Sep;52(3):473–476. doi: 10.1161/01.cir.52.3.473. [DOI] [PubMed] [Google Scholar]
  21. Steele P., Battock D., Pappas G., Genton E. Correlation of platelet survival time with occlusion of saphenous vein aorto-coronary bypass grafts. Circulation. 1976 Apr;53(4):685–687. doi: 10.1161/01.cir.53.4.685. [DOI] [PubMed] [Google Scholar]
  22. Stuart M. J., Murphy S., Oski F. A. A simple nonradioisotope technic for the determination of platelet life-span. N Engl J Med. 1975 Jun 19;292(25):1310–1313. doi: 10.1056/NEJM197506192922502. [DOI] [PubMed] [Google Scholar]
  23. Unni K. K., Kottke B. A., Titus J. L., Frye R. L., Wallace R. B., Brown A. L. Pathologic changes in aortocoronary saphenous vein grafts. Am J Cardiol. 1974 Oct 3;34(5):526–532. doi: 10.1016/0002-9149(74)90122-2. [DOI] [PubMed] [Google Scholar]
  24. Vlodaver Z., Edwards J. E. Pathologic analysis in fatal cases following saphenous vein coronary arterial bypass. Chest. 1973 Nov;64(5):555–563. doi: 10.1378/chest.64.5.555. [DOI] [PubMed] [Google Scholar]
  25. Vlodaver Z., Edwards J. E. Pathologic changes in aortic-coronary arterial saphenous vein grafts. Circulation. 1971 Oct;44(4):719–728. doi: 10.1161/01.cir.44.4.719. [DOI] [PubMed] [Google Scholar]

Articles from Canadian Medical Association Journal are provided here courtesy of Canadian Medical Association

RESOURCES