Abstract
We compared the effects of acyclovir (ACV) and 9-(1,3-dihydroxy-2-propoxymethyl)guanine (DHPG) on murine cytomegalovirus (MCMV) replication in lung and salivary gland tissues, the evolution of interstitial pneumonitis in vivo, and MCMV replication in mouse embryo cells in vitro. As measured by plaque reduction, ACV was more active than DHPG in vitro. In vivo, whether administered orally by gastric intubation or in the drinking water, or subcutaneously, DHPG was more effective than ACV in reducing MCMV titers in lung or salivary gland tissues. This was true in both normal and cyclophosphamide-treated mice. Neither drug was able to prevent MCMV interstitial pneumonitis, despite substantial reductions in virus titer, but both drugs reduced the severity of the pneumonitis.
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Selected References
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- Blum M. R., Liao S. H., de Miranda P. Overview of acyclovir pharmacokinetic disposition in adults and children. Am J Med. 1982 Jul 20;73(1A):186–192. doi: 10.1016/0002-9343(82)90088-2. [DOI] [PubMed] [Google Scholar]
- Burns W. H., Wingard J. R., Bender W. J., Saral R. Thymidine kinase not required for antiviral activity of acyclovir against mouse cytomegalovirus. J Virol. 1981 Sep;39(3):889–893. doi: 10.1128/jvi.39.3.889-893.1981. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Glasgow L. A., Richards J. T., Kern E. R. Effect of acyclovir treatment on acute and chronic murine cytomegalovirus infection. Am J Med. 1982 Jul 20;73(1A):132–137. doi: 10.1016/0002-9343(82)90078-x. [DOI] [PubMed] [Google Scholar]
- Meyers J. D., McGuffin R. W., Neiman P. E., Singer J. W., Thomas E. D. Toxicity and efficacy of human leukocyte interferon for treatment of cytomegalovirus pneumonia after marrow transplantation. J Infect Dis. 1980 May;141(5):555–562. doi: 10.1093/infdis/141.5.555. [DOI] [PubMed] [Google Scholar]
- Selgrade M. K., Osborn J. E. Role of macrophages in resistance to murine cytomegalovirus. Infect Immun. 1974 Dec;10(6):1383–1390. doi: 10.1128/iai.10.6.1383-1390.1974. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Shanley J. D., Jordan M. C., Cook M. L., Stevens J. G. Pathogenesis of reactivated latent murine cytomegalovirus infection. Am J Pathol. 1979 Apr;95(1):67–80. [PMC free article] [PubMed] [Google Scholar]
- Shanley J. D., Pesanti E. L., Nugent K. M. The pathogenesis of pneumonitis due to murine cytomegalovirus. J Infect Dis. 1982 Sep;146(3):388–396. doi: 10.1093/infdis/146.3.388. [DOI] [PubMed] [Google Scholar]
- Shanley J. D., Pesanti E. L. The relation of viral replication to interstitial pneumonitis in murine cytomegalovirus lung infection. J Infect Dis. 1985 Mar;151(3):454–458. doi: 10.1093/infdis/151.3.454. [DOI] [PubMed] [Google Scholar]
- Wade J. C., Hintz M., McGuffin R., Springmeyer S. C., Connor J. D., Meyers J. D. Treatment of cytomegalovirus pneumonia with high-dose acyclovir. Am J Med. 1982 Jul 20;73(1A):249–256. doi: 10.1016/0002-9343(82)90100-0. [DOI] [PubMed] [Google Scholar]
- Wade J. C., McGuffin R. W., Springmeyer S. C., Newton B., Singer J. W., Meyers J. D. Treatment of cytomegaloviral pneumonia with high-dose acyclovir and human leukocyte interferon. J Infect Dis. 1983 Sep;148(3):557–562. doi: 10.1093/infdis/148.3.557. [DOI] [PubMed] [Google Scholar]
- Wingard J. R., Bender W. J., Saral R., Burns W. H. Efficacy of acyclovir against mouse cytomegalovirus in vivo. Antimicrob Agents Chemother. 1981 Aug;20(2):275–278. doi: 10.1128/aac.20.2.275. [DOI] [PMC free article] [PubMed] [Google Scholar]