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. 1986 Mar;29(3):506–508. doi: 10.1128/aac.29.3.506

Quinolones affect thymidine incorporation into the DNA of human lymphocytes.

A Forsgren, A K Bergh, M Brandt, G Hansson
PMCID: PMC180422  PMID: 3717944

Abstract

The incorporation of [3H]thymidine into DNA was increased in phytohemagglutinin-stimulated human lymphocytes exposed to four of the new quinolone derivatives (ciprofloxacin, norfloxacin, ofloxacin, and A 56620) at concentrations achievable in clinical situations. However, proliferation of phytohemagglutinin-stimulated lymphocytes was not influenced by ciprofloxacin at concentrations of 0.5 to 10 micrograms/ml.

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Selected References

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  1. Arvidson S., Holme T., Wadström T. Formation of bacteriolytic enzymes in batch and continuous culture of Staphylococcus aureus. J Bacteriol. 1970 Oct;104(1):227–233. doi: 10.1128/jb.104.1.227-233.1970. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Banck G., Forsgren A. Antibiotics and suppression of lymphocyte function in vitro. Antimicrob Agents Chemother. 1979 Nov;16(5):554–560. doi: 10.1128/aac.16.5.554. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Banck G., Forsgren A. Many bacterial species are mitogenic for human blood B lymphocytes. Scand J Immunol. 1978;8(4):347–354. doi: 10.1111/j.1365-3083.1978.tb00528.x. [DOI] [PubMed] [Google Scholar]
  4. Bellahsene A., Forsgren A. Effect of doxycycline on immune response in mice. Infect Immun. 1985 May;48(2):556–559. doi: 10.1128/iai.48.2.556-559.1985. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Bellahsène A., Forsgren A. Effect of fusidic acid on the immune response in mice. Infect Immun. 1980 Sep;29(3):873–878. doi: 10.1128/iai.29.3.873-878.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Bellahsène A., Forsgren A. Effect of rifampin on the immune response in mice. Infect Immun. 1980 Jan;27(1):15–20. doi: 10.1128/iai.27.1.15-20.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Forsgren A., Banck G., Beckman H., Bellahsène A. Antibiotic-host defence interactions in vitro and in vivo. Scand J Infect Dis Suppl. 1980;Suppl 24:195–203. [PubMed] [Google Scholar]
  8. Forsgren A. Comparative in vitro activity of three new quinolone antibiotics against recent clinical isolates. Scand J Infect Dis. 1985;17(1):91–94. doi: 10.3109/00365548509070426. [DOI] [PubMed] [Google Scholar]
  9. Forsgren A., Svedjelund A., Wigzell H. Lymphocyte stimulation by protein A of Staphylococcus aureus. Eur J Immunol. 1976 Mar;6(3):207–213. doi: 10.1002/eji.1830060312. [DOI] [PubMed] [Google Scholar]
  10. Rijkers G. T., Van Oosterom R., Van Muiswinkel W. B. The immune system of cyprinid fish. Oxytetracycline and the regulation of humoral immunity in carp (Cyprinus carpio). Vet Immunol Immunopathol. 1981 Jun;2(3):281–290. doi: 10.1016/0165-2427(81)90029-5. [DOI] [PubMed] [Google Scholar]
  11. Thong Y. H., Ferrante A. Effect of tetracycline treatment on immunological responses in mice. Clin Exp Immunol. 1980 Mar;39(3):728–732. [PMC free article] [PubMed] [Google Scholar]
  12. Van den Bogert C., Kroon A. M. Effects of oxytetracycline on in vivo proliferation and differentiation of erythroid and lymphoid cells in the rat. Clin Exp Immunol. 1982 Nov;50(2):327–335. [PMC free article] [PubMed] [Google Scholar]

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